CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036680
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Stathmin 
Protein Synonyms/Alias
  
Gene Name
 STMN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48QAFELILKPPSPISEubiquitination[1]
108HEREVLQKALEENNNacetylation[2]
108HEREVLQKALEENNNubiquitination[1, 3, 4, 5]
118EENNNFSKMAEEKLIacetylation[5]
118EENNNFSKMAEEKLIubiquitination[1, 3, 4, 5]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 168 AA 
Protein Sequence
MKELSMLSLI CSCFYPEPRN INIYTYDDME VKQINKRASG QAFELILKPP SPISEAPRTL 60
ASPKKKDLSL EEIQKKLEAA EERRKSQEAQ VLKQLAEKRE HEREVLQKAL EENNNFSKMA 120
EEKLILKMEQ IKENREANLA AIIERLQEKE RHAAEVRRNK ELQVELSG 168 
Gene Ontology
 GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:InterPro. 
Interpro
 IPR026729; Stathmin-2.
 IPR000956; Stathmin_fam. 
Pfam
 PF00836; Stathmin 
SMART
  
PROSITE
 PS00563; STATHMIN_1
 PS01041; STATHMIN_2 
PRINTS
 PR00345; STATHMIN.