CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044688
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Polycomb protein SUZ12 
Protein Synonyms/Alias
  
Gene Name
 SUZ12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92LFLQAFEKPTQIYRFubiquitination[1]
318WETILDGKRLPPFETubiquitination[1, 2, 3, 4]
345WTGETNDKSTAPIAKubiquitination[1, 2]
352KSTAPIAKPLATRNSubiquitination[2, 4]
514VCRPKRTKASMSEFLubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 716 AA 
Protein Sequence
MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA VAAATASGGK SGGGSCGGGG SYSASSSSSA 60
AAAAGAAVLP VKKPKMEHVQ ADHELFLQAF EKPTQIYRFL RTRNLIAPIF LHRTLTYMSH 120
RNSRTNIKSL SAHLQLTFTG FFHKNDKPSP NSENEQNSVT LEVLLVKVCH KKRKDVSCPI 180
RQVPTGKKQV PLNPDLNQTK PGNFPSLAVS SNEFEPSNSH MVKSYSLLFR VTRPGRREFN 240
GMINGETNEN IDVNEELPAR RKRNREDGEK TFVAQMTVFD KNRRLQLLDG EYEVAMQEME 300
ECPISKKRAT WETILDGKRL PPFETFSQGP TLQFTLRWTG ETNDKSTAPI AKPLATRNSE 360
SLHQENKPGS VKPTQTIAVK ESLTTDLQTR KEKDTPNENR QKLRIFYQFL YNNNTRQQTE 420
ARDDLHCPWC TLNCRKLYSL LKHLKLCHSR FIFNYVYHPK GARIDVSINE CYDGSYAGNP 480
QDIHRQPGFA FSRNGPVKRT PITHILVCRP KRTKASMSEF LESEDGEVEQ QRTYSSGHNR 540
LYFHSDTCLP LRPQEMEVDS EDEKDPEWLR EKTITQIEEF SDVNEGEKEV MKLWNLHVMK 600
HGFIADNQMN HACMLFVENY GQKIIKKNLC RNFMLHLVSM HDFNLISIMS IDKAVTKLRE 660
MQQKLEKGES ASPANEEITE EQNGTANGFS EINSKEKALE TDSVSGVSKQ SKKQKL 716 
Gene Ontology
  
Interpro
 IPR019135; Polycomb_protein_VEFS-Box.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF09733; VEFS-Box 
SMART
 SM00355; ZnF_C2H2 
PROSITE
  
PRINTS