UniProt Accession

 PSPA_ECOLI; P0AFM6; P23853; P76040; P77363 

Genbank Protein ID

 X57560; U00096; AP009048 

Genbank Nucleotide ID

 CAA40789.1; AAC74386.1; BAA14873.1 

Protein Name

 Phage shock protein A 

Protein Synonyms/Alias

  

Gene Name

 pspA 

Gene Synonyms/Alias

 b1304; JW1297 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
21	NINALLEKAEDPQKL	acetylation	[1]
27	EKAEDPQKLVRLMIQ	acetylation	[1]
74	REVEWQEKAELALLK	acetylation	[1]
81	KAELALLKEREDLAR	acetylation	[1]
94	ARAALIEKQKLTDLI	acetylation	[1]
96	AALIEKQKLTDLIKS	acetylation	[1]
102	QKLTDLIKSLEHEVT	acetylation	[1]
119	DDTLARMKKEIGELE	acetylation	[1]
120	DTLARMKKEIGELEN	acetylation	[1]
128	EIGELENKLSETRAR	acetylation	[1]
160	RRQLDSGKLDEAMAR	acetylation	[1]
189	AESHSFGKQKSLDDQ	acetylation	[1]
191	SHSFGKQKSLDDQFA	acetylation	[1]
201	DDQFAELKADDAISE	acetylation	[1]
214	SEQLAQLKAKMKQDN	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force. 

Sequence Annotation

  

Keyword

 Cell inner membrane; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0009271; P:phage shock; IEP:EcoliWiki.
 GO:0009408; P:response to heat; IEP:EcoliWiki. 

Interpro

 IPR014319; Phageshock_PspA.
 IPR007157; PspA_IM30. 

Pfam

 PF04012; PspA_IM30 

SMART

  

PROSITE

  

PRINTS