| Tag | Content |
|---|
| CPLM ID | CPLM-019994 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hsp70-binding protein 1 |
Protein Synonyms/Alias | HspBP1; Heat shock protein-binding protein 1; Hsp70-interacting protein 1 |
Gene Name | Hspbp1 |
Gene Synonyms/Alias | Hspbp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | AMQQQVQKLKVKSAF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). |
Sequence Annotation | REPEAT 130 172 ARM 1.
REPEAT 175 215 ARM 2.
REPEAT 218 257 ARM 3.
REPEAT 260 299 ARM 4.
MOD_RES 349 349 Phosphoserine (By similarity).
MOD_RES 354 354 Phosphoserine (By similarity). |
Keyword | Complete proteome; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 357 AA |
Protein Sequence | MADKGSGGSR LPLALPPASQ GCSSGGSGSS AGGSGNPRPP RNLQGLLQMA ITAGSQEPDP 60
PPEPMSEERR QWLQEAMSAA FRGQREEVEQ MKNCLRVLSQ ATPAMAGEAE LATDQQEREG 120
ALELLADLCE NMDNAADFCQ LSGMHLLVGR YLEAGAAGLR WRAAQLIGTC SQNVAAIQEQ 180
VLGLGALRKL LRLLDRDSCD TVRVKALFAI SCLVREQEAG LLQFLRLDGF SVLMRAMQQQ 240
VQKLKVKSAF LLQNLLVGHP EHKGTLCSMG MVQQLVALVR TEHSPFHEHV LGALCSLVTD 300
FPQGVRECRE PELGLEELLR HRCQLLQQRE EYQEELEFCE KLLQTCFSSP TDDSMDR 357 |
Gene Ontology | GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara. GO:0031398; P:positive regulation of protein ubiquitination; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |