| Tag | Content |
|---|
| CPLM ID | CPLM-007210 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA damage-responsive transcriptional repressor RPH1 |
Protein Synonyms/Alias | |
Gene Name | RPH1 |
Gene Synonyms/Alias | YER169W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 665 | KSNLILSKVASTRQE | acetylation | [1] | | 694 | GSSPLNSKFAPEEIV | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Transcriptional repressor of photolyase PHR1. Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1. Derepresses PHR1 transcription when phosphorylated. |
Sequence Annotation | DOMAIN 14 55 JmjN.
DOMAIN 193 355 JmjC.
ZN_FING 709 732 C2H2-type 1.
ZN_FING 738 763 C2H2-type 2; atypical.
MOTIF 455 471 Bipartite nuclear localization signal.
MOD_RES 399 399 Phosphothreonine.
MOD_RES 430 430 Phosphoserine.
MOD_RES 459 459 Phosphoserine.
MOD_RES 557 557 Phosphoserine.
MOD_RES 561 561 Phosphoserine.
MOD_RES 575 575 Phosphoserine.
MOD_RES 584 584 Phosphoserine.
MOD_RES 652 652 Phosphoserine.
MOD_RES 689 689 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 796 AA |
Protein Sequence | MTKLIAPSEI VGGVPVFKPT YEQFEDFYAY CKAINKYGMK SGVVKVIPPK EWKDKLDLPY 60
SAETLQKIKI KSPIQQHISG NKGLFMVQNV EKNKTYNIIQ WKDLSKDYVP PEDPKARRNS 120
RKGSVSKSTK LKLKNFESSF NIDDFEQFRT EYTIDLSDFQ NTERLKFLEE YYWKTLNFTT 180
PMYGADTPGS IFPEGLNVWN VAKLPNILDH METKVPGVND SYLYAGLWKA SFSWHLEDQD 240
LYSINYIHFG APKQWYSIPQ EDRFKFYKFM QEQFPEEAKN CPEFLRHKMF LASPKLLQEN 300
GIRCNEIVHH EGEFMITYPY GYHAGFNYGY NLAESVNFAL EEWLPIGKKA GKCHCISDSV 360
EIDVKKLAKS WRDNNKESKG TPPLNQLPNP AMPLLHRPTL KEMESSSLRS TSPDVGHFSN 420
FKSKSSGVSS PLLSRMKDYS NIVEPTLEDP TLKLKRISSF QEQPLNKLLK RETSQTAMLT 480
DHEDNIVAMS LTSMANSAAS SPRLPLSRLN SSNELSNAQP LLDMTNNTLA FPRPNGPSGL 540
NPLLYISNKN ISGISHSAPH SPVNPNISLI KRVKSPNIVT LNISRESSRS PIALNYEARQ 600
QHSQQHSFST PSTVSNLSTS VLGPLSDTND IKTPHPERPN HKTANRILKK ESPVETSKSN 660
LILSKVASTR QEDSFTSRND DLDKEQGSSP LNSKFAPEEI VLSGKNKIYI CKECQRKFSS 720
GHHLTRHKKS VHSGEKPHSC PKCGKRFKRR DHVLQHLNKK IPCISNETTV DAPIMNPTVQ 780
PQDGKAAINQ QSTPLN 796 |
Gene Ontology | GO:0005634; C:nucleus; IC:SGD. GO:0051864; F:histone demethylase activity (H3-K36 specific); IDA:SGD. GO:0032454; F:histone demethylase activity (H3-K9 specific); IDA:SGD. GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:SGD. GO:0043565; F:sequence-specific DNA binding; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |