CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011700
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Small cell adhesion glycoprotein 
Protein Synonyms/Alias
 Small transmembrane and glycosylated protein 
Gene Name
 SMAGP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88QMESDLAKGSEKEEYubiquitination[1]
92DLAKGSEKEEYFI**ubiquitination[1, 2, 3, 4, 5, 6, 7]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation. 
Sequence Annotation
 CARBOHYD 2 2 O-linked (GalNAc...) (Potential).
 CARBOHYD 3 3 O-linked (GalNAc...) (Potential).
 CARBOHYD 6 6 O-linked (GalNAc...) (Potential).
 CARBOHYD 7 7 O-linked (GalNAc...) (Potential).
 CARBOHYD 9 9 O-linked (GalNAc...) (Potential).
 CARBOHYD 16 16 O-linked (GalNAc...) (Potential).
 CARBOHYD 17 17 O-linked (GalNAc...) (Potential).
 CARBOHYD 23 23 O-linked (GalNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Reference proteome; Sialic acid; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 97 AA 
Protein Sequence
MTSLLTTPSP REELMTTPIL QPTEALSPED GASTALIAVV ITVVFLTLLS VVILIFFYLY 60
KNKGSYVTYE PTEGEPSAIV QMESDLAKGS EKEEYFI 97 
Gene Ontology
 GO:0030054; C:cell junction; IDA:HPA.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS