CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019270
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polycomb protein SCMH1 
Protein Synonyms/Alias
 Sex comb on midleg homolog 1 
Gene Name
 SCMH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
276QPGQRGRKPGKKRGRacetylation[1]
279QRGRKPGKKRGRTPKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes (By similarity). 
Sequence Annotation
 REPEAT 28 126 MBT 1.
 REPEAT 134 235 MBT 2.
 DOMAIN 593 658 SAM.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Developmental protein; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 660 AA 
Protein Sequence
MLVCYSVLAC EILWDLPCSI MGSPLGHFTW DKYLKETCSV PAPVHCFKQS YTPPSNEFKI 60
SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSAEI QPIGNCEKNG 120
GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIRIFHKEPP SPSHNFFKMG MKLEAVDRKN 180
PHFICPATIG EVRGSEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD NLQPPGTKVV 240
IPKNPYPASD VNTEKPSIHS STKTVLEHQP GQRGRKPGKK RGRTPKTLIS HPISAPSKTA 300
EPLKFPKKRG PKPGSKRKPR TLLNPPPASP TTSTPEPDTS TVPQDAATIP SSAMQAPTVC 360
IYLNKNGSTG PHLDKKKVQQ LPDHFGPARA SVVLQQAVQA CIDCAYHQKT VFSFLKQGHG 420
GEVISAVFDR EQHTLNLPAV NSITYVLRFL EKLCHNLRSD NLFGNQPFTQ THLSLTAIEY 480
SHSHDRYLPG ETFVLGNSLA RSLEPHSDSM DSASNPTNLV STSQRHRPLL SSCGLPPSTA 540
SAVRRLCSRG VLKGSNERRD MESFWKLNRS PGSDRYLESR DASRLSGRDP SSWTVEDVMQ 600
FVREADPQLG PHADLFRKHE IDGKALLLLR SDMMMKYMGL KLGPALKLSY HIDRLKQGKF 660 
Gene Ontology
 GO:0010369; C:chromocenter; IEA:Compara.
 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0006338; P:chromatin remodeling; IEA:Compara.
 GO:0016458; P:gene silencing; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR021987; DUF3588.
 IPR004092; Mbt.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF12140; DUF3588
 PF02820; MBT
 PF00536; SAM_1 
SMART
 SM00561; MBT
 SM00454; SAM 
PROSITE
 PS51079; MBT
 PS50105; SAM_DOMAIN 
PRINTS