UniProt Accession

 KGUA_YEAST; P15454; D6VT79 

Genbank Protein ID

 L04683; U33007; BK006938 

Genbank Nucleotide ID

 AAA34657.1; AAB64881.1; DAA12289.1 

Protein Name

 Guanylate kinase 

Protein Synonyms/Alias

 GMP kinase 

Gene Name

 GUK1 

Gene Synonyms/Alias

 YDR454C; D9461.39 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
21	GKSTLLKKLFAEYPD	ubiquitination	[1]
60	FVSVDEFKSMIKNNE	acetylation	[2]
130	PPSVEDLKKRLEGRG	acetylation	[2]
146	ETEESINKRLSAAQA	acetylation	[2]
146	ETEESINKRLSAAQA	ubiquitination	[1]
174	IVNDDLDKAYKELKD	acetylation	[2]
180	DKAYKELKDFIFAEK	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Essential for recycling GMP and indirectly, cGMP. 

Sequence Annotation

 DOMAIN 2 184 Guanylate kinase-like.
 NP_BIND 9 16 ATP.
 NP_BIND 35 82 GMP.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 149 149 Phosphoserine.
 MOD_RES 157 157 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004385; F:guanylate kinase activity; ISS:UniProtKB.
 GO:0046037; P:GMP metabolic process; TAS:SGD. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR017665; Guanylate_kinase_sub.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00625; Guanylate_kin 

SMART

 SM00072; GuKc 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2 

PRINTS