CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019615
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipase maturation factor 1 
Protein Synonyms/Alias
 Transmembrane protein 112 
Gene Name
 LMF1 
Gene Synonyms/Alias
 C16orf26; TMEM112; HMFN1876; JFP11 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92LPCRVFLKNFQQYFQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 567 AA 
Protein Sequence
MRPDSPTMAA PAESLRRRKT GYSDPEPESP PAPGRGPAGS PAHLHTGTFW LTRIVLLKAL 60
AFVYFVAFLV AFHQNKQLIG DRGLLPCRVF LKNFQQYFQD RTSWEVFSYM PTILWLMDWS 120
DMNSNLDLLA LLGLGISSFV LITGCANMLL MAALWGLYMS LVNVGHVWYS FGWESQLLET 180
GFLGIFLCPL WTLSRLPQHT PTSRIVLWGF RWLIFRIMLG AGLIKIRGDR CWRDLTCMDF 240
HYETQPMPNP VAYYLHHSPW WFHRFETLSN HFIELLVPFF LFLGRRACII HGVLQILFQA 300
VLIVSGNLSF LNWLTMVPSL ACFDDATLGF LFPSGPGSLK DRVLQMQRDI RGARPEPRFG 360
SVVRRAANVS LGVLLAWLSV PVVLNLLSSR QVMNTHFNSL HIVNTYGAFG SITKERAEVI 420
LQGTASSNAS APDAMWEDYE FKCKPGDPSR RPCLISPYHY RLDWLMWFAA FQTYEHNDWI 480
IHLAGKLLAS DAEALSLLAH NPFAGRPPPR WVRGEHYRYK FSRPGGRHAA EGKWWVRKRI 540
GAYFPPLSLE ELRPYFRDRG WPLPGPL 567 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0034382; P:chylomicron remnant clearance; IEA:Compara.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Compara.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0033578; P:protein glycosylation in Golgi; IEA:Compara.
 GO:0051604; P:protein maturation; IEA:Compara.
 GO:0009306; P:protein secretion; IEA:Compara.
 GO:0090181; P:regulation of cholesterol metabolic process; IEA:Compara.
 GO:0090207; P:regulation of triglyceride metabolic process; IEA:Compara. 
Interpro
 IPR009613; LMF. 
Pfam
 PF06762; LMF1 
SMART
  
PROSITE
  
PRINTS