CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006785
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-1-phosphate thymidylyltransferase 1 
Protein Synonyms/Alias
 G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 
Gene Name
 rmlA1 
Gene Synonyms/Alias
 rfbA; rmlA; b2039; JW2024 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
153YGVVEFDKNGTAISLacetylation[1]
163TAISLEEKPLEPKSNacetylation[1]
191VQMAKNLKPSARGELacetylation[1]
271IDVEQVRKLAVPLIKacetylation[1]
278KLAVPLIKNNYGQYLacetylation[1]
287NYGQYLYKMTKDSN*acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. 
Sequence Annotation
 METAL 111 111 Magnesium (By similarity).
 METAL 226 226 Magnesium (By similarity).  
Keyword
 3D-structure; Complete proteome; Lipopolysaccharide biosynthesis; Magnesium; Metal-binding; Nucleotidyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 293 AA 
Protein Sequence
MKMRKGIILA GGSGTRLYPV TMAVSKQLLP IYDKPMIYYP LSTLMLAGIR DILIISTPQD 60
TPRFQQLLGD GSQWGLNLQY KVQPSPDGLA QAFIIGEEFI GGDDCALVLG DNIFYGHDLP 120
KLMEAAVNKE SGATVFAYHV NDPERYGVVE FDKNGTAISL EEKPLEPKSN YAVTGLYFYD 180
NDVVQMAKNL KPSARGELEI TDINRIYLEQ GRLSVAMMGR GYAWLDTGTH QSLIEASNFI 240
ATIEERQGLK VSCPEEIAFR KGFIDVEQVR KLAVPLIKNN YGQYLYKMTK DSN 293 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
 GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR005907; G1P_thy_trans_s.
 IPR005835; NTP_transferase. 
Pfam
 PF00483; NTP_transferase 
SMART
  
PROSITE
  
PRINTS