CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tigger transposable element-derived protein 5 
Protein Synonyms/Alias
  
Gene Name
 TIGD5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
204PAPGPPVKEEPALPSubiquitination[1]
310LRHHNQDKFPASYRYubiquitination[2]
341EEFVPGVKRYLRRSCubiquitination[1, 2, 3]
406VRVLFLSKGSSRAHIubiquitination[2, 4]
426QGVVAAFKQLYKRELubiquitination[2]
430AAFKQLYKRELLRLAubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 DOMAIN 47 98 HTH psq-type.
 DOMAIN 112 185 HTH CENPB-type.
 DOMAIN 233 357 DDE 1.
 DOMAIN 410 477 DDE 2.
 DNA_BIND 74 94 H-T-H motif (By similarity).
 DNA_BIND 145 178 H-T-H motif (By similarity).  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 642 AA 
Protein Sequence
MYPAGPPAGP VPRRGRRPLP GPPAPAPAPV PAARPPPPAP GPRPRVAVKM AFRKAYSIKD 60
KLQAIERVKG GERQASVCRD FGVPGGTLRG WLKDEPKLRW FLEQLGGEVG TQRKKMRLAN 120
EEEIDRAVYA WFLALRQHGV PLSGPLIQAQ AEAFARQIYG PECTFKASHG WFWRWQKRHG 180
ISSQRFYGEA GPPAPSPAPG PPVKEEPALP SGAGPLPDRA PAPPPPAEGG YGDEQIYSAS 240
VTGLYWKLLP EQAAPPGAGD PGAGGCGRRW RGDRVTVLLA ANLTGSHKLK PLVIGRLPDP 300
PSLRHHNQDK FPASYRYSPD AWLSRPLLRG WFFEEFVPGV KRYLRRSCLQ QKAVLLVAHP 360
PCPSPAASMP ALDSEDAPVR CRPEPLGPPE ELQTPDGAVR VLFLSKGSSR AHIPAPLEQG 420
VVAAFKQLYK RELLRLAVSC ASGSPLDFMR SFMLKDMLYL AGLSWDLVQA GSIERCWLLG 480
LRAAFEPRPG EDSAGQPAQA EEAAEHSRVL SDLTHLAALA YKCLAPEEVA EWLHLDDDGG 540
PPEGCREEVG PALPPAAPPA PASLPSAMGG GEDEEEATDY GGTSVPTAGE AVRGLETALR 600
WLENQDPREV GPLRLVQLRS LISMARRLGG IGHTPAGPYD GV 642 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom.
 IPR007889; HTH_Psq. 
Pfam
 PF04218; CENP-B_N
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5 
SMART
 SM00674; CENPB 
PROSITE
 PS51253; HTH_CENPB
 PS50960; HTH_PSQ 
PRINTS