CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein claret segregational 
Protein Synonyms/Alias
  
Gene Name
 ncd 
Gene Synonyms/Alias
 CA(ND); CG7831 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
205RFHDLLEKHKVLKTKacetylation[1]
558SRSHAVTKLELIGRHacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule's minus end. 
Sequence Annotation
 DOMAIN 347 700 Kinesin-motor.
 NP_BIND 434 441 ATP (By similarity).
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 96 96 Phosphoserine.  
Keyword
 3D-structure; ATP-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Meiosis; Microtubule; Mitosis; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MESRLPKPSG LKKPQMPIKT VLPTDRIRAG LGGGAAGAGA FNVNANQTYC GNLLPPLSRD 60
LNNLPQVLER RGGGARAASP EPMKLGHRAK LRRSRSACDI NELRGNKRTA AAPSLPSIPS 120
KVSRLGGALT VSSQRLVRPA APSSITATAV KRPPVTRPAP RAAGGAAAKK PAGTGAAASS 180
GAAAAAPKRI APYDFKARFH DLLEKHKVLK TKYEKQTEDM GELESMPQQL EETQNKLIET 240
ESSLKNTQSD NECLQRQVKQ HTAKIETITS TLGRTKEELS ELQAIHEKVK TEHAALSTEV 300
VHLRQRTEEL LRCNEQQAAE LETCKEQLFQ SNMERKELHN TVMDLRGNIR VFCRIRPPLE 360
SEENRMCCTW TYHDESTVEL QSIDAQAKSK MGQQIFSFDQ VFHPLSSQSD IFEMVSPLIQ 420
SALDGYNICI FAYGQTGSGK TYTMDGVPES VGVIPRTVDL LFDSIRGYRN LGWEYEIKAT 480
FLEIYNEVLY DLLSNEQKDM EIRMAKNNKN DIYVSNITEE TVLDPNHLRH LMHTAKMNRA 540
TASTAGNERS SRSHAVTKLE LIGRHAEKQE ISVGSINLVD LAGSESPKTS TRMTETKNIN 600
RSLSELTNVI LALLQKQDHI PYRNSKLTHL LMPSLGGNSK TLMFINVSPF QDCFQESVKS 660
LRFAASVNSC KMTKAKRNRY LNNSVANSST QSNNSGSFDK 700 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005871; C:kinesin complex; ISS:FlyBase.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005819; C:spindle; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008569; F:minus-end-directed microtubule motor activity; NAS:FlyBase.
 GO:0042803; F:protein homodimerization activity; IDA:FlyBase.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051298; P:centrosome duplication; IMP:FlyBase.
 GO:0032837; P:distributive segregation; IMP:FlyBase.
 GO:0001578; P:microtubule bundle formation; IDA:FlyBase.
 GO:0031534; P:minus-end directed microtubule sliding; IDA:FlyBase.
 GO:0007100; P:mitotic centrosome separation; IMP:FlyBase.
 GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.
 GO:0032888; P:regulation of mitotic spindle elongation; IMP:FlyBase.
 GO:1901673; P:regulation of spindle assembly involved in mitosis; IGI:FlyBase.
 GO:0007056; P:spindle assembly involved in female meiosis; NAS:FlyBase.
 GO:0090307; P:spindle assembly involved in mitosis; IMP:FlyBase. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.