UniProt Accession

 EPT1_HUMAN; Q9C0D9; Q63ZE3 

Genbank Protein ID

 BK001426; AB051511 

Genbank Nucleotide ID

 DAA01514.1; BAB21815.1 

Protein Name

 Ethanolaminephosphotransferase 1 

Protein Synonyms/Alias

 hEPT1; Selenoprotein I; SelI 

Gene Name

 EPT1 

Gene Synonyms/Alias

 KIAA1724; SELI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	EQLAGFDKYKYSAVD	ubiquitination	[1]
19	LAGFDKYKYSAVDTN	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Complete proteome; Lipid biosynthesis; Lipid metabolism; Magnesium; Manganese; Membrane; Metal-binding; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Selenocysteine; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004307; F:ethanolaminephosphotransferase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006646; P:phosphatidylethanolamine biosynthetic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000462; CDP-OH_P_trans.
 IPR014472; CHOPT. 

Pfam

 PF01066; CDP-OH_P_transf 

SMART

  

PROSITE

 PS00379; CDP_ALCOHOL_P_TRANSF 

PRINTS