CPLM-017679

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017679

UniProt Accession

NAV1_HUMAN; Q8NEY1; A8MS88; Q5SVH1; Q5SVH2; Q5SVH3; Q5SVH7; Q5VUY9; Q8IVL2; Q96II1; Q9H7V9; Q9H9S9; Q9H9T5; Q9UGI1; Q9ULK7; Q9ULR9

Genbank Protein ID

AY043013; AL512788; AC092800; AL645504; AL645504; AC092800; AL512788; AL645504; AL645504; AL645504; AL645504; AC092800; AC096677; AJ251973; AJ488101; AB032977; AB033039; AK022622; AK022631; AK024265; BC007523

Genbank Nucleotide ID

AAL05591.1; CAH71925.1; CAH71925.1; CAH71925.1; CAI17010.1; CAI17010.1; CAI17010.1; CAI17011.1; CAI17012.1; CAI17013.1; CAI17014.1; CAI17014.1; CAB66088.1; CAD32470.1; BAA86465.3; BAA86527.1; BAB14136.1; BAB14142.1; BAB14865.1; AAH07523.1

Protein Name

Neuron navigator 1

Protein Synonyms/Alias

Pore membrane and/or filament-interacting-like protein 3; Steerin-1; Unc-53 homolog 1; unc53H1

Gene Name

NAV1

Gene Synonyms/Alias

KIAA1151; KIAA1213; POMFIL3; STEERIN1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
207	DDELLSSKAKAQKSS	ubiquitination	[1]
1317	LRSELWEKEMKLTDI	methylation	[2]
1320	ELWEKEMKLTDIRLE	methylation	[2]

Reference

[1] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[2] Large-scale global identification of protein lysine methylation in vivo.
Cao XJ, Arnaudo AM, Garcia BA.
Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]

Functional Description

May be involved in neuronal migration (By similarity).

Sequence Annotation

MOD_RES 90 90 Phosphoserine.
MOD_RES 142 142 Phosphoserine.
MOD_RES 152 152 Phosphoserine.
MOD_RES 159 159 Phosphothreonine.
MOD_RES 199 199 Phosphoserine.
MOD_RES 296 296 Phosphoserine.
MOD_RES 308 308 Phosphoserine.
MOD_RES 362 362 Phosphoserine.
MOD_RES 391 391 Phosphoserine.
MOD_RES 452 452 Phosphoserine.
MOD_RES 534 534 Phosphothreonine.
MOD_RES 572 572 Phosphothreonine.
MOD_RES 750 750 Phosphoserine.
MOD_RES 760 760 Phosphoserine.
MOD_RES 808 808 Phosphoserine.
MOD_RES 1000 1000 Phosphoserine.
MOD_RES 1006 1006 Phosphothreonine.
MOD_RES 1170 1170 Phosphothreonine.
MOD_RES 1181 1181 Phosphoserine.
MOD_RES 1265 1265 Phosphoserine.
MOD_RES 1382 1382 Phosphoserine.

Keyword

Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Microtubule; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1877 AA

Protein Sequence

MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 60
AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 120
GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 180
EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 240
GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 300
PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 360
RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 420
SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 480
PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 540
SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 600
TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 660
APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 720
VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 780
PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 840
FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 900
STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 960
RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA 1020
AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSAEERMQS 1080
EQIRKLRREL ESSQEKVATL TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL 1140
DLRETIDFLK KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS 1200
KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA PSSPKLQHGS 1260
TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE EPEKKEVSEL RSELWEKEMK 1320
LTDIRLEALN SAHQLDQLRE TMHNMQLEVD LLKAENDRLK VAPGPSSGST PGQVPGSSAL 1380
SSPRRSLGLA LTHSFGPSLA DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ 1440
EFFLGCSKVS GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA 1500
EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK HRRLVLSGPS 1560
GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD LQLYLSNLAN QIDRETGIGD 1620
VPLVILLDDL SEAGSISELV NGALTCKYHK CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS 1680
NNVEPANGFL VRYLRRKLVE SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI 1740
GPCFFLSCPI GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP 1800
WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML LKLQEAANYI 1860
ESPDRETILD PNLQATL 1877

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0001578; P:microtubule bundle formation; IEA:Compara.
GO:0001764; P:neuron migration; IEA:Compara.

Interpro

IPR003593; AAA+_ATPase.
IPR027417; P-loop_NTPase.

Pfam

SMART

SM00382; AAA

PROSITE

PRINTS