UniProt Accession

 KYNU_RAT; P70712; Q68G25; Q7M0D0; Q9QW90 

Genbank Protein ID

 U68168; BC078762 

Genbank Nucleotide ID

 AAC53206.1; AAH78762.1 

Protein Name

 Kynureninase 

Protein Synonyms/Alias

 L-kynurenine hydrolase 

Gene Name

 Kynu 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
38	LRLDEEDKLKRFKDC	acetylation	[1]
40	LDEEDKLKRFKDCFY	acetylation	[1]
84	GLQPKMVKTYLEEEL	acetylation	[1]
121	ESIVSLMKDIVGAHE	acetylation	[1]
157	KPTPKRHKILLEAKA	acetylation	[1]
416	ISKKGVFKELEKRGV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. 

Sequence Annotation

 REGION 165 168 Pyridoxal phosphate binding (By
 BINDING 137 137 Pyridoxal phosphate; via amide nitrogen
 BINDING 138 138 Pyridoxal phosphate (By similarity).
 BINDING 221 221 Pyridoxal phosphate (By similarity).
 BINDING 250 250 Pyridoxal phosphate (By similarity).
 BINDING 253 253 Pyridoxal phosphate (By similarity).
 BINDING 275 275 Pyridoxal phosphate (By similarity).
 BINDING 305 305 Pyridoxal phosphate (By similarity).
 BINDING 333 333 Pyridoxal phosphate (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 276 276 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Pyridine nucleotide biosynthesis; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030429; F:kynureninase activity; IDA:RGD.
 GO:0030170; F:pyridoxal phosphate binding; IDA:RGD.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0097053; P:L-kynurenine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0034341; P:response to interferon-gamma; IEA:Compara.
 GO:0034516; P:response to vitamin B6; IEA:Compara.
 GO:0019442; P:tryptophan catabolic process to acetyl-CoA; IDA:RGD.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IDA:RGD. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR010111; Kynureninase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

  

PRINTS