UniProt Accession

 1A01_HUMAN; P30443; O77964; O78171; Q9MYA3; Q9TP25; Q9TQP5 

Genbank Protein ID

 M24043; X55710; Z93949; AJ278305; BC003069; U07161; Y12469; Y12470; AH008863; AH007762; AH009407 

Genbank Nucleotide ID

 AAA59652.1; CAA39243.1; CAB07989.1; CAB93537.1; AAH03069.1; AAA80569.1; CAA73072.1; CAA73073.1; AAF19525.1; AAD33894.1; AAF73862.1 

Protein Name

 HLA class I histocompatibility antigen, A-1 alpha chain 

Protein Synonyms/Alias

 MHC class I antigen A*1 

Gene Name

 HLA-A 

Gene Synonyms/Alias

 HLAA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	DSDAASQKMEPRAPW	ubiquitination	[1, 2]
92	DQETRNMKAHSQTDR	ubiquitination	[1, 2]
145	RQDAYDGKDYIALNE	ubiquitination	[1, 2]
168	DMAAQITKRKWEAVH	ubiquitination	[1, 2, 3]
170	AAQITKRKWEAVHAA	ubiquitination	[1]
267	AGDGTFQKWAAVVVP	ubiquitination	[1, 2, 3]
292	VQHEGLPKPLTLRWE	ubiquitination	[1]
340	RRKSSDRKGGSYTQA	ubiquitination	[1]
364	DVSLTACKV******	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 209 295 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 308 Connecting peptide.
 MOD_RES 83 83 Sulfotyrosine (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...).
 DISULFID 125 188
 DISULFID 227 283  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Immunoglobulin domain; Membrane; MHC I; Polymorphism; Reference proteome; Signal; Sulfation; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; TAS:Reactome.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
 GO:0016045; P:detection of bacterium; IMP:UniProtKB.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.