CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HEAT repeat-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 HEATR3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
631IKLLSALKEFQPVFKubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 REPEAT 38 69 HEAT 1.
 REPEAT 74 110 HEAT 2.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 680 AA 
Protein Sequence
MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP SAEVRECACA 60
GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA GALRNLSACG GFEVCDDMVT 120
KDIMTPLVAL LKECSAGLDS NEMSLQEKKD QNRNSIENIA NETVNVLWNI CECSSRAVSI 180
FNKEGCLEIV LKYLSRFPTN VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP 240
VSSMESLLLK TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET 300
QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD KELRETIALL 360
TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS FSECGGQLFS PLCLSHEVHT 420
ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP TWKPLIRKMN TIQCRALFCL QSLVSLLDVE 480
HLGGAAALQT LAQHLSQLLF SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL 540
MTLCKAGIHS SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA 600
GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS TDQLCVLDNV 660
KMNLRRFIAY QETVEKRLTS 680 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS