CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin NUP188 homolog 
Protein Synonyms/Alias
 hNup188 
Gene Name
 NUP188 
Gene Synonyms/Alias
 KIAA0169 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
233ETSSVVRKIGGTAIQubiquitination[1]
370YNELYKHKPHDVISHubiquitination[1]
389LWRRQTPKLLYPLGGubiquitination[1]
517LAARNPAKVWTDLRHubiquitination[1]
701GQGQLLIKTVKLAFSubiquitination[1]
1298SLMEQLLKTLRYNFLubiquitination[1]
1616GKSTSLSKASPESQEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May function as a component of the nuclear pore complex (NPC). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 1709 1709 Phosphoserine.
 MOD_RES 1717 1717 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1749 AA 
Protein Sequence
MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK 60
VKANKDVASP LKELGLRISK FLGLDEEQSV QLLQCYLQED YRGTRDSVKT VLQDEMAPSD 120
LLVLTKMFKE QGFGSRQTNR HLVDETMDPF VDRIGYFSAL ILVEGMDIES LHKCALDDRR 180
ELHQFAQDGL ICQDMDCLML TFGDIPHHAP VLLAWALLRH TLNPEETSSV VRKIGGTAIQ 240
LNVFQYLTRL LQSLASGGND CTTSTACMCV YGLLSFVLTS LELHTLGNQQ DIIDTACEVL 300
ADPSLPELFW GTEPTSGLGI ILDSVCGMFP HLLSPLLQLL RALVSGKSTA KKVYSFLDKM 360
SFYNELYKHK PHDVISHEDG TLWRRQTPKL LYPLGGQTNL RIPQGTVGQV MLDDRAYLVR 420
WEYSYSSWTL FTCEIEMLLH VVSTADVIQH CQRVKPIIDL VHKVISTDLS IADCLLPITS 480
RIYMLLQRLT TVISPPVDVI ASCVNCLTVL AARNPAKVWT DLRHTGFLPF VAHPVSSLSQ 540
MISAEGMNAG GYGNLLMNSE QPQGEYGVTI AFLRLITTLV KGQLGSTQSQ GLVPCVMFVL 600
KEMLPSYHKW RYNSHGVREQ IGCLILELIH AILNLCHETD LHSSHTPSLQ FLCICSLAYT 660
EAGQTVINIM GIGVDTIDMV MAAQPRSDGA EGQGQGQLLI KTVKLAFSVT NNVIRLKPPS 720
NVVSPLEQAL SQHGAHGNNL IAVLAKYIYH KHDPALPRLA IQLLKRLATV APMSVYACLG 780
NDAAAIRDAF LTRLQSKIED MRIKVMILEF LTVAVETQPG LIELFLNLEV KDGSDGSKEF 840
SLGMWSCLHA VLELIDSQQQ DRYWCPPLLH RAAIAFLHAL WQDRRDSAML VLRTKPKFWE 900
NLTSPLFGTL SPPSETSEPS ILETCALIMK IICLEIYYVV KGSLDQSLKD TLKKFSIEKR 960
FAYWSGYVKS LAVHVAETEG SSCTSLLEYQ MLVSAWRMLL IIATTHADIM HLTDSVVRRQ 1020
LFLDVLDGTK ALLLVPASVN CLRLGSMKCT LLLILLRQWK RELGSVDEIL GPLTEILEGV 1080
LQADQQLMEK TKAKVFSAFI TVLQMKEMKV SDIPQYSQLV LNVCETLQEE VIALFDQTRH 1140
SLALGSATED KDSMETDDCS RSRHRDQRDG VCVLGLHLAK ELCEVDEDGD SWLQVTRRLP 1200
ILPTLLTTLE VSLRMKQNLH FTEATLHLLL TLARTQQGAT AVAGAGITQS ICLPLLSVYQ 1260
LSTNGTAQTP SASRKSLDAP SWPGVYRLSM SLMEQLLKTL RYNFLPEALD FVGVHQERTL 1320
QCLNAVRTVQ SLACLEEADH TVGFILQLSN FMKEWHFHLP QLMRDIQVNL GYLCQACTSL 1380
LHSRKMLQHY LQNKNGDGLP SAVAQRVQRP PSAASAAPSS SKQPAADTEA SEQQALHTVQ 1440
YGLLKILSKT LAALRHFTPD VCQILLDQSL DLAEYNFLFA LSFTTPTFDS EVAPSFGTLL 1500
ATVNVALNML GELDKKKEPL TQAVGLSTQA EGTRTLKSLL MFTMENCFYL LISQAMRYLR 1560
DPAVHPRDKQ RMKQELSSEL STLLSSLSRY FRRGAPSSPA TGVLPSPQGK STSLSKASPE 1620
SQEPLIQLVQ AFVRHMQR 1638 
Gene Ontology
 GO:0005635; C:nuclear envelope; TAS:Reactome.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 
Interpro
 IPR018864; Nucleoporin_Nup188. 
Pfam
 PF10487; Nup188 
SMART
  
PROSITE
  
PRINTS