| Tag | Content |
|---|
| CPLM ID | CPLM-002954 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nickel-responsive regulator |
Protein Synonyms/Alias | |
Gene Name | nikR |
Gene Synonyms/Alias | yhhG; b3481; JW3446 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 64 | SYVYEHEKRDLASRI | acetylation | [1] | | 131 | GHLQCLPKED***** | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. |
Sequence Annotation | METAL 76 76 Nickel.
METAL 87 87 Nickel.
METAL 89 89 Nickel.
METAL 95 95 Nickel. |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Metal-binding; Nickel; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 133 AA |
Protein Sequence | MQRVTITLDD DLLETLDSLS QRRGYNNRSE AIRDILRSAL AQEATQQHGT QGFAVLSYVY 60
EHEKRDLASR IVSTQHHHHD LSVATLHVHI NHDDCLEIAV LKGDMGDVQH FADDVIAQRG 120
VRHGHLQCLP KED 133 |
Gene Ontology | GO:0032993; C:protein-DNA complex; IDA:EcoCyc. GO:0003677; F:DNA binding; IDA:EcoCyc. GO:0016151; F:nickel cation binding; TAS:EcoCyc. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:HAMAP. GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc. GO:0010045; P:response to nickel cation; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |