UniProt Accession

 HYEP_MOUSE; Q9D379; P97869 

Genbank Protein ID

 U89491; AK018249; CH466555; BC045194; BC061493 

Genbank Nucleotide ID

 AAB49762.1; BAB31132.1; EDL13136.1; AAH45194.1; AAH61493.1 

Protein Name

 Epoxide hydrolase 1 

Protein Synonyms/Alias

 Epoxide hydratase; Microsomal epoxide hydrolase 

Gene Name

 Ephx1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	PGSKPSAKEDESIRP	ubiquitination	[1]
52	DESIRPFKVETSDEE	acetylation	[2]
52	DESIRPFKVETSDEE	ubiquitination	[1]
61	ETSDEEIKDLHQRID	acetylation	[2]
61	ETSDEEIKDLHQRID	ubiquitination	[1]
91	GFNSSYLKKVVSFWR	ubiquitination	[1]
92	FNSSYLKKVVSFWRN	ubiquitination	[1]
105	RNEFDWRKQVEILNQ	ubiquitination	[1]
117	LNQYPHFKTKIEGLD	ubiquitination	[1]
142	LPSGRTPKPLLMVHG	ubiquitination	[1]
197	FSEASSKKGLNSVAT	ubiquitination	[1]
277	RFLGYTEKDLELLYP	ubiquitination	[1]
286	LELLYPFKEKVFYNI	ubiquitination	[1]
288	LLYPFKEKVFYNIMR	ubiquitination	[1]
334	EKFSTWTKSEYRELE	ubiquitination	[1]
375	VSSQRFYKENLGQGV	ubiquitination	[1]
411	EILHAPEKWVKVKYP	ubiquitination	[1]
419	WVKVKYPKLISYSYM	ubiquitination	[1]
439	FAAFEEPKLLAQDIR	acetylation	[2]
439	FAAFEEPKLLAQDIR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. 

Sequence Annotation

 MOD_RES 295 295 Omega-N-methylated arginine (By  

Keyword

 Aromatic hydrocarbons catabolism; Complete proteome; Detoxification; Direct protein sequencing; Endoplasmic reticulum; Hydrolase; Membrane; Methylation; Microsome; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 455 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033961; F:cis-stilbene-oxide hydrolase activity; IEA:EC.
 GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
 GO:0006725; P:cellular aromatic compound metabolic process; IMP:MGI.
 GO:0014070; P:response to organic cyclic compound; IMP:MGI.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. 

Interpro

 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like.
 IPR010497; Epoxide_hydro_N.
 IPR016292; Epoxide_hydrolase. 

Pfam

 PF00561; Abhydrolase_1
 PF06441; EHN 

SMART

  

PROSITE

  

PRINTS

 PR00412; EPOXHYDRLASE.