UniProt Accession

 SDHF2_HUMAN; Q9NX18 

Genbank Protein ID

 AK000494; BC002331 

Genbank Nucleotide ID

 BAA91204.1; AAH02331.1 

Protein Name

 Succinate dehydrogenase assembly factor 2, mitochondrial 

Protein Synonyms/Alias

 SDH assembly factor 2; Succinate dehydrogenase subunit 5, mitochondrial; hSDH5 

Gene Name

 SDHAF2 

Gene Synonyms/Alias

 C11orf79; PGL2; SDH5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	TDESIETKRARLLYE	ubiquitination	[1, 2]
100	HLQHMTEKQLNLYDR	ubiquitination	[3, 4]
145	ALLRDFAKNKNKEQR	ubiquitination	[2]
147	LRDFAKNKNKEQRLR	ubiquitination	[2]
164	DLEYLFEKPR*****	ubiquitination	[2, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment. 

Sequence Annotation

  

Keyword

 Complete proteome; Disease mutation; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 166 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IMP:UniProtKB.
 GO:0018293; P:protein-FAD linkage; IMP:UniProtKB. 

Interpro

 IPR005631; DUF339. 

Pfam

 PF03937; Sdh5 

SMART

  

PROSITE

  

PRINTS