CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017037
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho GTPase-activating protein 12 
Protein Synonyms/Alias
 Rho-type GTPase-activating protein 12 
Gene Name
 ARHGAP12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
306TRDASISKGDFQNPGubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). 
Sequence Annotation
 DOMAIN 12 74 SH3.
 DOMAIN 265 298 WW 1.
 DOMAIN 358 391 WW 2.
 DOMAIN 463 575 PH.
 DOMAIN 656 844 Rho-GAP.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 201 201 Phosphoserine.
 MOD_RES 206 206 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine.
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 231 231 Phosphothreonine (By similarity).
 MOD_RES 240 240 Phosphoserine.
 MOD_RES 243 243 Phosphotyrosine.
 MOD_RES 521 521 Phosphothreonine (By similarity).
 MOD_RES 592 592 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 846 AA 
Protein Sequence
MKMADRSGKI IPGQVYIEVE YDYEYEAKDR KIVIKQGERY ILVKKTNDDW WQVKPDENSK 60
AFYVPAQYVK EVTRKALMPP VKQVAGLPNN STKIMQSLHL QRSTENVNKL PELSSFGKPS 120
SSVQGTGLIR DANQNFGPSY NQGQTVNLSL DLTHNNGKFN NDSHSPKVSS QNRTRSFGHF 180
PGPEFLDVEK TSFSQEQSCD SAGEGSERIH QDSESGDELS SSSTEQIRAT TPPNQGRPDS 240
PVYANLQELK ISQSALPPLP GSPAIQINGE WETHKDSSGR CYYYNRGTQE RTWKPPRWTR 300
DASISKGDFQ NPGDQELLSS EENYYSTSYS QSDSQCGSPP RGWSEELDER GHTLYTSDYT 360
NEKWLKHVDD QGRQYYYSAD GSRSEWELPK YNASSQQQRE IIKSRSLDRR LQEPIVLTKW 420
RHSTIVLDTN DKESPTASKP CFPENESSPS SPKHQDTASS PKDQEKYGLL NVTKIAENGK 480
KVRKNWLSSW AVLQGSSLLF TKTQGSSTSW FGSNQSKPEF TVDLKGATIE MASKDKSSKK 540
NVFELKTRQG TELLIQSDND TVINDWFKVL SSTINNQAVE TDEGIEEEIP DSPGIEKHDK 600
EKEQKDPKKL RSFKVSSIDS SEQKKTKKNL KKFLTRRPTL QAVREKGYIK DQVFGSNLAN 660
LCQRENGTVP KFVKLCIEHV EEHGLDIDGI YRVSGNLAVI QKLRFAVNHD EKLDLNDSKW 720
EDIHVITGAL KMFFRELPEP LFTFNHFNDF VNAIKQEPRQ RVAAVKDLIR QLPKPNQDTM 780
QILFRHLRRV IENGEKNRMT YQSIAIVFGP TLLKPEKETG NIAVHTVYQN QIVELILLEL 840
SSIFGR 846 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015767; Rho_GTPase_activating.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001452; SH3_domain.
 IPR001202; WW_dom. 
Pfam
 PF00169; PH
 PF00620; RhoGAP
 PF00397; WW 
SMART
 SM00233; PH
 SM00324; RhoGAP
 SM00326; SH3
 SM00456; WW 
PROSITE
 PS50003; PH_DOMAIN
 PS50238; RHOGAP
 PS50002; SH3
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS