CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018398
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Triosephosphate isomerase 
Protein Synonyms/Alias
 TIM; Triose-phosphate isomerase 
Gene Name
 tpiA 
Gene Synonyms/Alias
 STM4081 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
111ESDELIAKKFAVLKEacetylation[1]
112SDELIAKKFAVLKEQacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 ACT_SITE 95 95 Electrophile (By similarity).
 ACT_SITE 167 167 Proton acceptor (By similarity).
 BINDING 9 9 Substrate (By similarity).
 BINDING 11 11 Substrate (By similarity).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Pentose shunt; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 255 AA 
Protein Sequence
MRHPLVMGNW KLNGSRHMVN ELVANLRKEL TGVAGCDVAI APPEMYIDLA KRAAAGSHIM 60
LGAQNVDLNL SGAFTGETSA EMLKDIGAQY IIIGHSERRT YHKESDELIA KKFAVLKEQG 120
LTPVLCIGET EAENEAGKTE EVCARQIDAV LKTQGAAAFE GAVIAYEPVW AIGTGKSATP 180
AQAQAVHKFI RDHIAKADAK IAEQVIIQYG GSVNASNAAE LFAQPDIDGA LVGGASLKAD 240
AFAVIVKAAE AAKQA 255 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
 GO:0006094; P:gluconeogenesis; IEA:HAMAP.
 GO:0006096; P:glycolysis; IEA:HAMAP.
 GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR022896; TrioseP_Isoase_bac/euk.
 IPR000652; Triosephosphate_isomerase.
 IPR020861; Triosephosphate_isomerase_AS. 
Pfam
 PF00121; TIM 
SMART
  
PROSITE
 PS00171; TIM_1
 PS51440; TIM_2 
PRINTS