UniProt Accession

 KAP1_HUMAN; P31321; Q8N422 

Genbank Protein ID

 M65066; AK315951; AK315990; BC026734; BC036828 

Genbank Nucleotide ID

 AAC37564.1; BAH14322.1; BAH14361.1; AAH26734.1; AAH36828.2 

Protein Name

 cAMP-dependent protein kinase type I-beta regulatory subunit 

Protein Synonyms/Alias

  

Gene Name

 PRKAR1B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
222	VKAKTDLKLWGIDRD	ubiquitination	[1]
244	GSTLRKRKMYEEFLS	ubiquitination	[1]
261	SILESLEKWERLTVA	ubiquitination	[1, 2]
346	VVARGPLKCVKLDRP	ubiquitination	[1]
349	RGPLKCVKLDRPRFE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. 

Sequence Annotation

 NP_BIND 137 254 cAMP 1.
 NP_BIND 255 381 cAMP 2.
 REGION 2 136 Dimerization and phosphorylation.
 MOTIF 96 100 Pseudophosphorylation motif.
 BINDING 202 202 cAMP 1.
 BINDING 211 211 cAMP 1.
 BINDING 326 326 cAMP 2.
 BINDING 335 335 cAMP 2.
 MOD_RES 2 2 N-acetylalanine (Probable).
 MOD_RES 21 21 Nitrated tyrosine.
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 83 83 Phosphoserine.
 DISULFID 18 18 Interchain (with C-39) (By similarity).
 DISULFID 39 39 Interchain (with C-18) (By similarity).  

Keyword

 3D-structure; Acetylation; cAMP; cAMP-binding; Cell membrane; Complete proteome; Disulfide bond; Membrane; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; NAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; NAS:UniProtKB.
 GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.
 GO:0034199; P:activation of protein kinase A activity; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0006468; P:protein phosphorylation; NAS:UniProtKB.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0006833; P:water transport; TAS:Reactome. 

Interpro

 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 

Pfam

 PF00027; cNMP_binding
 PF02197; RIIa 

SMART

 SM00100; cNMP
 SM00394; RIIa 

PROSITE

 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 

PRINTS

 PR00103; CAMPKINASE.