CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040453
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent L-type calcium channel subunit alpha-1C 
Protein Synonyms/Alias
  
Gene Name
 Cacna1c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1566KEQGLVGKPSQRNALubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2063 AA 
Protein Sequence
ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD 60
GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI 120
IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA EEDPSPCALE TGHGRQCQNG TVCKPGWDGP 180
KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWVNDAVGRD WPWIYFVTLI IIGSFFVLNL 240
VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
KPRNRGAPAG LHDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI EGENCGARLA 360
HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV FLNTLTIASE HYNQPHWLTE 420
VQDTANKALL ALFTAEMLLK MYSLGLQAYF VSLFNRFDCF IVCGGILETI LVETKIMSPL 480
GISVLRCVRL LRIFKITRYW NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG 540
GKFNFDEMQT RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI 600
ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP EKKQEVMEKP 660
AVEESKEEKI ELKSITADGE SPPTTKINMD DLQPSENEDK SPHSNPDTAG EEDEEEPEMP 720
VGPRPRPLSE LHLKEKAVPM PEASAFFIFS PNNRFRLQCH RIVNDTIFTN LILFFILLSS 780
ISLAAEDPVQ HTSFRNHILG NADYVFTSIF TLEIILKMTA YGAFLHKGSF CRNYFNILDL 840
LVVSVSLISF GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI 900
VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP IIQPRSWENS 960
KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP IYNYRVEISI FFIIYIIIIA 1020
FFMMNIFVGF VIVTFQEQGE QEYKNCELDK NQRQCVEYAL KARPLRRYIP KNQHQYKVWY 1080
VVNSTYFEYL MFVLILLNTI CLAMQHYGQS CLFKIAMNIL NMLFTGLFTV EMILKLIAFK 1140
PKHYFCDAWN TFDALIVVGS IVDIAITEVH PAEHTQCSPS MVRTTLQTTF PASVAPPLAT 1200
HVLSTLISRA LGTQPSSHCM WPPCPLCALT ACAHVSCARS AEENSRISIT FFRLFRVMRL 1260
VKLLSRGEGI RTLLWTFIKS FQALPYVALL IVMLFFIYAV IGMQVFGKIA LNDTTEINRN 1320
NNFQTFPQAV LLLFRCATGE AWQDIMLACM PGKKCAPESE PSNSTEGETP CGSSFAVFYF 1380
ISFYMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FKRIWAEYDP EAKGRIKHLD 1440
VVTLLRRIQP PLGFGKLCPH RVACKRLVSM NMPLNSDGTV MFNATLFALV RTALRIKTEG 1500
NLEQANEELR AIIKKIWKRT SMKLLDQVVP PAGDDEVTVG KFYATFLIQE YFRKFKKRKE 1560
QGLVGKPSQR NALSLQAGLR TLHDIGPEIR RAISGDLTAE EELDKAMKEA VSAASEDDIF 1620
RRAGGLFGNH VTYYQSDSRG NFPQTFATQR PLHINKTGNN QADTESPSHE KLVDSTFTPS 1680
SYSSTGSNAN INNANNTALG RFPHPAGYSS TVSTVEGHGP PLSPAVRVQE AAWKLSSKRC 1740
HSRESQGATV NQEIFPDETR SVRMSEEAEY CSEPSLLSTD MFSYQEDEHR QLTCPEEDKR 1800
EIQPSPKRSF LRSASLGRRA SFHLECLKRQ KDQGGDISQK TALPLHLVHH QALAVAGLSP 1860
LLQRSHSPTT FPRPCPTPPV TPGSRGRPLR PIPTLRLEGA ESSEKLNSSF PSIHCSSWSE 1920
ETTACSGSSS MARRARPVSL TVPSQAGAPG RQFHGSASSL VEAVLISEGL GQFAQDPKFI 1980
EVTTQELADA CDMTIEEMEN AADNILSGGA QQSPNGTLLP FVNCRDPGQD RAVAPEDESC 2040
AYALGRGRSE EALADSRSYV SNL 2063 
Gene Ontology
 GO:0002095; C:caveolar macromolecular signaling complex; IDA:MGI.
 GO:0043198; C:dendritic shaft; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0030315; C:T-tubule; TAS:MGI.
 GO:0005891; C:voltage-gated calcium channel complex; TAS:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005245; F:voltage-gated calcium channel activity; IDA:MGI.
 GO:0007628; P:adult walking behavior; IGI:MGI.
 GO:0017156; P:calcium ion-dependent exocytosis; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0030252; P:growth hormone secretion; IDA:MGI.
 GO:0030073; P:insulin secretion; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0046620; P:regulation of organ growth; IMP:MGI.
 GO:0019229; P:regulation of vasoconstriction; IMP:MGI.
 GO:0060083; P:smooth muscle contraction involved in micturition; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI.
 GO:0008542; P:visual learning; IMP:MGI. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005451; VDCC_L_a1csu.
 IPR005446; VDCC_L_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM01062; Ca_chan_IQ 
PROSITE
  
PRINTS
 PR00167; CACHANNEL.
 PR01630; LVDCCALPHA1.
 PR01635; LVDCCALPHA1C.