UniProt Accession

 VAMP1_HUMAN; P23763; A8MVP3; D3DUR3; O75468; Q15857; Q6FG94; Q8IVC9 

Genbank Protein ID

 M36200; M36196; M36197; M36198; M36199; AF060538; Z48924; CR542214; CR542231; CR749485; AC005840; CH471116; CH471116; CH471116; BC023286 

Genbank Nucleotide ID

 AAA60603.1; AAA60603.1; AAA60603.1; AAA60603.1; AAA60603.1; AAC28336.1; CAA88760.1; CAG47010.1; CAG47027.1; CAH18312.1; EAW88792.1; EAW88795.1; EAW88796.1; AAH23286.1 

Protein Name

 Vesicle-associated membrane protein 1 

Protein Synonyms/Alias

 VAMP-1; Synaptobrevin-1 

Gene Name

 VAMP1 

Gene Synonyms/Alias

 SYB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	IIRVNVDKVLERDQK	ubiquitination	[1, 2, 3, 4]
61	KVLERDQKLSELDDR	ubiquitination	[3]
85	QFESSAAKLKRKYWW	ubiquitination	[3]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Involved in the targeting and/or fusion of transport vesicles to their target membrane. 

Sequence Annotation

 DOMAIN 33 93 v-SNARE coiled-coil homology.
 MOD_RES 63 63 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Synapse; Synaptosome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.