CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014259
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase Mer 
Protein Synonyms/Alias
 Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK 
Gene Name
 Mertk 
Gene Synonyms/Alias
 Mer 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
610QEDGTSQKVAVKTMKubiquitination[1]
851VLRLQLEKLSESLPDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. 
Sequence Annotation
 DOMAIN 75 181 Ig-like C2-type 1.
 DOMAIN 192 268 Ig-like C2-type 2.
 DOMAIN 279 374 Fibronectin type-III 1.
 DOMAIN 378 477 Fibronectin type-III 2.
 DOMAIN 582 852 Protein kinase.
 NP_BIND 588 596 ATP (By similarity).
 ACT_SITE 718 718 Proton acceptor (By similarity).
 BINDING 610 610 ATP (By similarity).
 MOD_RES 538 538 Phosphoserine (By similarity).
 MOD_RES 744 744 Phosphotyrosine; by autocatalysis (By
 MOD_RES 748 748 Phosphotyrosine; by autocatalysis (By
 MOD_RES 749 749 Phosphotyrosine; by autocatalysis (By
 MOD_RES 867 867 Phosphotyrosine; by autocatalysis.
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 CARBOHYD 165 165 N-linked (GlcNAc...) (Potential).
 CARBOHYD 202 202 N-linked (GlcNAc...) (Potential).
 CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).
 CARBOHYD 289 289 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 CARBOHYD 324 324 N-linked (GlcNAc...) (Potential).
 CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
 CARBOHYD 349 349 N-linked (GlcNAc...) (Potential).
 CARBOHYD 384 384 N-linked (GlcNAc...) (Potential).
 CARBOHYD 390 390 N-linked (GlcNAc...) (Potential).
 CARBOHYD 437 437 N-linked (GlcNAc...) (Potential).
 CARBOHYD 449 449 N-linked (GlcNAc...) (Potential).
 DISULFID 109 170 By similarity.
 DISULFID 213 257 By similarity.  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 994 AA 
Protein Sequence
MVLAPLLLGL LLLPALWSGG TAEKWEETEL DQLFSGPLPG RLPVNHRPFS APHSSRDQLP 60
PPQTGRSHPA HTAAPQVTST ASKLLPPVAF NHTIGHIVLS EHKNVKFNCS INIPNTYQET 120
AGISWWKDGK ELLGAHHSIT QFYPDEEGVS IIALFSIASV QRSDNGSYFC KMKVNNREIV 180
SDPIYVEVQG LPYFIKQPES VNVTRNTAFN LTCQAVGPPE PVNIFWVQNS SRVNEKPERS 240
PSVLTVPGLT ETAVFSCEAH NDKGLTVSKG VHINIKVIPS PPTEVHILNS TAHSILVSWV 300
PGFDGYSPLQ NCSIQVKEAD RLSNGSVMVF NTSASPHLYE IQQLQALANY SIAVSCRNEI 360
GWSAVSPWIL ASTTEGAPSV APLNITVFLN ESNNILDIRW TKPPIKRQDG ELVGYRISHV 420
WESAGTYKEL SEEVSQNGSW AQIPVQIHNA TCTVRIAAIT KGGIGPFSEP VNIIIPEHSK 480
VDYAPSSTPA PGNTDSMFII LGCFCGFILI GLILCISLAL RRRVQETKFG GAFSEEDSQL 540
VVNYRAKKSF CRRAIELTLQ SLGVSEELQN KLEDVVIDRN LLVLGKVLGE GEFGSVMEGN 600
LKQEDGTSQK VAVKTMKLDN FSQREIEEFL SEAACMKDFN HPNVIRLLGV CIELSSQGIP 660
KPMVILPFMK YGDLHTFLLY SRLNTGPKYI HLQTLLKFMM DIAQGMEYLS NRNFLHRDLA 720
ARNCMLRDDM TVCVADFGLS KKIYSGDYYR QGRIAKMPVK WIAIESLADR VYTSKSDVWA 780
FGVTMWEITT RGMTPYPGVQ NHEMYDYLLH GHRLKQPEDC LDELYDIMYS CWSADPLDRP 840
TFSVLRLQLE KLSESLPDAQ DKESIIYINT QLLESCEGIA NGPSLTGLDM NIDPDSIIAS 900
CTPGAAVSVV TAEVHENNLR EERYILNGGN EEWEDVSSTP FAAVTPEKDG VLPEDRLTKN 960
GVSWSHHSTL PLGSPSPDEL LFVDDSLEDS EVLM 994 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001750; C:photoreceptor outer segment; IEA:Compara.
 GO:0016028; C:rhabdomere; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
 GO:0043277; P:apoptotic cell clearance; IMP:UniProtKB.
 GO:0001779; P:natural killer cell differentiation; IGI:MGI.
 GO:0051250; P:negative regulation of lymphocyte activation; IGI:MGI.
 GO:0030168; P:platelet activation; IMP:MGI.
 GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IGI:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0032940; P:secretion by cell; IMP:MGI.
 GO:0007283; P:spermatogenesis; IGI:MGI.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IMP:MGI.
 GO:0060068; P:vagina development; IGI:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF00041; fn3
 PF07714; Pkinase_Tyr 
SMART
 SM00060; FN3
 SM00409; IG
 SM00219; TyrKc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.