CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033812
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium bicarbonate cotransporter 3 
Protein Synonyms/Alias
 Solute carrier family 4 sodium bicarbonate cotransporter member 7 
Gene Name
 SLC4A7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32EAVVDLGKTSSTVNTubiquitination[1]
1068SLLQIPVKALKYSVDubiquitination[1, 2, 3]
1071QIPVKALKYSVDPSIubiquitination[1, 2, 3, 4]
1087NISDEMAKTAQWKALubiquitination[1, 2, 3]
1092MAKTAQWKALSMNTEubiquitination[1, 2, 3, 4, 5]
1102SMNTENAKVTRSNMSubiquitination[1, 3]
1112RSNMSPDKPVSVKISubiquitination[1]
1117PDKPVSVKISFEDEPubiquitination[1, 2, 3]
1127FEDEPRKKYVDAETSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1135 AA 
Protein Sequence
MEADGAGEQM RPLLTRVTSR GPDEEAVVDL GKTSSTVNTK FEKEELESHR AVYIGVHVPF 60
SKESRRRHRH RGHKHHHRRR KDKESDKEDG RESPSYDTPS QRVQFILGTE DDDEEHIPHD 120
LFTEMDELCY RDGEEYEWKE TARWLKFEED VEDGGDRWSK PYVATLSLHS LFELRSCILN 180
GTVMLDMRAS TLDEIADMVL DNMIASGQLD ESIRENVREA LLKRHHHQNE KRFTSRIPLV 240
RSFADIGKKH SDPHLLERNG ILASPQSAPG NLDNSKSGEI KGNGSGGSRE NSTVDFSKVD 300
MNFMRKIPTG AEASNVLVGE VDFLERPIIA FVRLAPAVLL TGLTEVPVPT RFLFLLLGPA 360
GKAPQYHEIG RSIATLMTDE IFHDVAYKAK DRNDLLSGID EFLDQVTVLP PGEWDPSIRI 420
EPPKSVPSQE KRKIPVFHNG STPTLGETPK EAAHHAGPEL QRTGRLFGGL ILDIKRKAPF 480
FLSDFKDALS LQCLASILFL YCACMSPVIT FGGLLGEATE GRISAIESLF GASLTGIAYS 540
LFAGQPLTIL GSTGPVLVFE KILYKFCRDY QLSYLSLRTS IGLWTSFLCI VLVATDASSL 600
VCYITRFTEE AFAALICIIF IYEALEKLFD LGETYAFNMH NNLDKLTSYS CVCTEPPNPS 660
NETLAQWKKD NITAHNISWR NLTVSECKKL RGVFLGSACG HHGPYIPDVL FWCVILFFTT 720
FFLSSFLKQF KTKRYFPTKV RSTISDFAVF LTIVIMVTID YLVGVPSPKL HVPEKFEPTH 780
PERGWIISPL GDNPWWTLLI AAIPALLCTI LIFMDQQITA VIINRKEHKL KKGAGYHLDL 840
LMVGVMLGVC SVMGLPWFVA ATVLSISHVN SLKVESECSA PGEQPKFLGI REQRVTGLMI 900
FILMGLSVFM TSVLKFIPMP VLYGVFLYMG VSSLKGIQLF DRIKLFGMPA KHQPDLIYLR 960
YVPLWKVHIF TVIQLTCLVL LWVIKVSAAA VVFPMMVLAL VFVRKLMDLC FTKRELSWLD 1020
DLMPESKKKK EDDKKKKEKE EAERMLQDDD DTVHLPFEGG SLLQIPVKAL KYSVDPSIVN 1080
ISDEMAKTAQ WKALSMNTEN AKVTRSNMSP DKPVSVKISF EDEPRKKYVD AETSL 1135 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. 
Interpro
 IPR013769; Band3_cytoplasmic_dom.
 IPR011531; HCO3_transpt_C.
 IPR003020; HCO3_transpt_euk.
 IPR003024; Na/HCO3_transpt.
 IPR016152; PTrfase/Anion_transptr. 
Pfam
 PF07565; Band_3_cyto
 PF00955; HCO3_cotransp 
SMART
  
PROSITE
  
PRINTS
 PR01231; HCO3TRNSPORT.
 PR01232; NAHCO3TRSPRT.