UniProt Accession

 SGK2_MOUSE; Q9QZS5; B7ZC31; Q8R0P6 

Genbank Protein ID

 AF169033; AK050009; AL591584; BC026549 

Genbank Nucleotide ID

 AAF12756.1; BAC34031.1; CAX16089.1; AAH26549.1 

Protein Name

 Serine/threonine-protein kinase Sgk2 

Protein Synonyms/Alias

 Serum/glucocorticoid-regulated kinase 2 

Gene Name

 Sgk2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
271	LLQGLLHKDQRQRLG	ubiquitination	[1]
303	NWDDLYHKRLTPPFN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. 

Sequence Annotation

 DOMAIN 35 292 Protein kinase.
 DOMAIN 293 367 AGC-kinase C-terminal.
 NP_BIND 41 49 ATP (By similarity).
 MOTIF 68 78 Nuclear localization signal (By
 ACT_SITE 159 159 Proton acceptor (By similarity).
 BINDING 64 64 ATP (By similarity).
 MOD_RES 193 193 Phosphothreonine; by PDPK1 (By
 MOD_RES 356 356 Phosphoserine (Potential).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase
 PF00433; Pkinase_C 

SMART

 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS