| Tag | Content |
|---|
| CPLM ID | CPLM-007592 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leukemia inhibitory factor receptor |
Protein Synonyms/Alias | LIF receptor; LIF-R; D-factor/LIF receptor; CD118 |
Gene Name | Lifr |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 881 | CKALQFQKSVCEGSN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. |
Sequence Annotation | DOMAIN 45 126 Fibronectin type-III 1.
DOMAIN 327 423 Fibronectin type-III 2.
DOMAIN 428 522 Fibronectin type-III 3.
DOMAIN 530 620 Fibronectin type-III 4.
DOMAIN 622 714 Fibronectin type-III 5.
DOMAIN 719 824 Fibronectin type-III 6.
MOTIF 514 518 WSXWS motif.
MOTIF 864 872 Box 1 motif.
MOD_RES 922 922 Phosphoserine (By similarity).
CARBOHYD 164 164 N-linked (GlcNAc...).
CARBOHYD 199 199 N-linked (GlcNAc...).
CARBOHYD 238 238 N-linked (GlcNAc...).
CARBOHYD 261 261 N-linked (GlcNAc...).
CARBOHYD 385 385 N-linked (GlcNAc...).
CARBOHYD 402 402 N-linked (GlcNAc...).
CARBOHYD 421 421 N-linked (GlcNAc...).
CARBOHYD 440 440 N-linked (GlcNAc...).
CARBOHYD 453 453 N-linked (GlcNAc...).
CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
CARBOHYD 567 567 N-linked (GlcNAc...) (Potential).
CARBOHYD 647 647 N-linked (GlcNAc...) (Potential).
CARBOHYD 658 658 N-linked (GlcNAc...).
CARBOHYD 675 675 N-linked (GlcNAc...).
CARBOHYD 724 724 N-linked (GlcNAc...) (Potential).
CARBOHYD 782 782 N-linked (GlcNAc...) (Potential).
DISULFID 53 63
DISULFID 80 88
DISULFID 208 265
DISULFID 336 346
DISULFID 461 506 |
Keyword | 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1092 AA |
Protein Sequence | MAAYSWWRQP SWMVDNKRSR MTPNLPWLLS ALTLLHLTMH ANGLKRGVQD LKCTTNNMRV 60
WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA LSPGDHEVTI NYLNGFQSKF 120
TLNEKDVSLI PETPEILDLS ADFFTSSLLL KWNDRGSALP HPSNATWEIK VLQNPRTEPV 180
ALVLLNTMLS GKDTVQHWNW TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS 240
WIRNTETNVF PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP 300
VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP GRITGLVGPR 360
NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI HNFTLTGRNP LGQAQSAVVI 420
NVTERVAPHD PTSLKVKDIN STVVTFSWYL PGNFTKINLL CQIEICKANS KKEVRNATIR 480
GAEDSTYHVA VDKLNPYTAY TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW 540
SSDGKNLIVY WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII 600
SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC DYVIKWCNSS 660
RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT NQGYQLLRSI IGYVEELAPI 720
VAPNFTVEDT SADSILVKWD DIPVEELRGF LRGYLFYFQK GERDTPKTRS LEPHHSDIKL 780
KNITDISQKT LRIADLQGKT SYHLVLRAYT HGGLGPEKSM FVVTKENSVG LIIAILIPVA 840
VAVIVGVVTS ILCYRKREWI KETFYPDIPN PENCKALQFQ KSVCEGSNAL KTLEMNPCTP 900
NNVEVLESRS IVPKIEDTEI ISPVAERPGE RSEVDPENHV VVSYCPPIIE EEITNPAADE 960
VGGASQVVYI DVQSMYQPQA KAEEEQDVDP VVVAGYKPQM RLPISPAVED TAAEDEEGKT 1020
AGYRPQANVN TWNLVSPDSP RSTDSNNEVV SFGSPCSINS RQFLIPPKDE DSPKSNGGGW 1080
SFTNFFQNKP ND 1092 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004923; F:leukemia inhibitory factor receptor activity; IEA:Compara. GO:0004924; F:oncostatin-M receptor activity; IEA:Compara. GO:0008284; P:positive regulation of cell proliferation; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |