| Tag | Content |
|---|
| CPLM ID | CPLM-017171 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Putative N-acetylglucosamine-6-phosphate deacetylase |
Protein Synonyms/Alias | Amidohydrolase domain-containing protein 2; GlcNAc 6-P deacetylase |
Gene Name | Amdhd2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 43 | GRILDPEKLFFEERR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Hydrolyzes the N-glycolyl group from N- glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). |
Sequence Annotation | REGION 235 236 Substrate binding (By similarity).
REGION 328 330 Substrate binding (By similarity).
ACT_SITE 294 294 Proton donor/acceptor (By similarity).
METAL 143 143 Divalent metal cation (By similarity).
METAL 211 211 Divalent metal cation; via tele nitrogen
METAL 232 232 Divalent metal cation; via tele nitrogen
BINDING 154 154 Substrate; via amide nitrogen (By
BINDING 243 243 Substrate (By similarity).
BINDING 272 272 Substrate; via tele nitrogen (By |
Keyword | Carbohydrate metabolism; Complete proteome; Hydrolase; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 409 AA |
Protein Sequence | MRSGQCAAGA PVLQFTNCRI LRGGTLLRED LWVRGGRILD PEKLFFEERR VADEQRDCGG 60
RILAPGFIDV QINGGFGVDF SKATEDVGSG VALVARRLLS HGVTSFCPTL VTSPPEVYHK 120
VLPQIPVKSG GPHGAGVLGV HLEGPFISRE KRGAHPEAYL RSFEANAFHD VLATYGPLDN 180
VCIVTLAPEL DRSHEVIQAL TAQGIRVSLG HSVADLRAAE VAVQSGATFI THLFNAMLPF 240
HHRDPGIVGL LTSDQLPPGH CIFYGMIADG IHTNPAALRI AHRAHPQGLV LVTDAVPALG 300
LGNGRHTLGQ QEVEVDGLIA YIAGTKTLGG SIAPMDVCVR HFLQATGCSV ESALEAASLH 360
PAQMLGLEKT KGSLDFGADA DFVVLDDTLH VQATYISGEL VWQAEEAGP 409 |
Gene Ontology | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008448; F:N-acetylglucosamine-6-phosphate deacetylase activity; ISS:UniProtKB. GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW. GO:0006044; P:N-acetylglucosamine metabolic process; IEA:InterPro. GO:0019262; P:N-acetylneuraminate catabolic process; TAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |