UniProt Accession

 COX5A_HUMAN; P20674; P30045; Q8TB65 

Genbank Protein ID

 M22760; DQ987236; DQ987237; CR407649; AC125435; CH471136; BC024240 

Genbank Nucleotide ID

 AAA99220.1; ABK92283.1; ABK92284.1; CAG28577.1; EAW99288.1; AAH24240.1 

Protein Name

 Cytochrome c oxidase subunit 5A, mitochondrial 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide Va 

Gene Name

 COX5A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	RWVTYFNKPDIDAWE	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 

Sequence Annotation

  

Keyword

 Complete proteome; Direct protein sequencing; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003204; Cyt_c_oxidase_su5A/6. 

Pfam

 PF02284; COX5A 

SMART

  

PROSITE

  

PRINTS