UniProt Accession

 BABA1_HUMAN; Q9NWV8; A8MQT0; B4DRY9; B4DVR1; Q6FIA0; Q9P018 

Genbank Protein ID

 AF161491; AL136692; AK000578; AK299493; AK301193; CR533526; AC104522; BC000788; BC006244; BC091491 

Genbank Nucleotide ID

 AAF29106.1; CAB66627.1; BAA91268.1; BAG61451.1; BAG62773.1; CAG38557.1; AAH00788.1; AAH06244.1; AAH91491.1 

Protein Name

 BRISC and BRCA1-A complex member 1 

Protein Synonyms/Alias

 Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex 

Gene Name

 BABAM1 

Gene Synonyms/Alias

 C19orf62; MERIT40; NBA1; HSPC142 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	NALNVSQKMIEMFVR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. 

Sequence Annotation

 REGION 95 298 VWFA-like.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 62 62 Phosphoserine.
 MOD_RES 65 65 Phosphothreonine.
 MOD_RES 66 66 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; Cytoplasm; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0070531; C:BRCA1-A complex; IDA:UniProtKB.
 GO:0070552; C:BRISC complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; IMP:UniProtKB.
 GO:0031572; P:G2 DNA damage checkpoint; IMP:UniProtKB.
 GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.
 GO:0070536; P:protein K63-linked deubiquitination; IMP:UniProtKB.
 GO:0010212; P:response to ionizing radiation; IMP:UniProtKB. 

Interpro

 IPR026126; BABAM1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS