UniProt Accession

 KAP0_RAT; P09456 

Genbank Protein ID

 M17086 

Genbank Nucleotide ID

 AAB54276.1 

Protein Name

 cAMP-dependent protein kinase type I-alpha regulatory subunit 

Protein Synonyms/Alias

 cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 

Gene Name

 Prkar1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
59	EYFERLEKEEARQIQ	acetylation	[1]
261	SILESLDKWERLTVA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (By similarity). 

Sequence Annotation

 NP_BIND 137 254 cAMP 1.
 NP_BIND 255 381 cAMP 2.
 REGION 2 136 Dimerization and phosphorylation.
 MOTIF 96 100 Pseudophosphorylation motif.
 BINDING 202 202 cAMP 1.
 BINDING 211 211 cAMP 1.
 BINDING 326 326 cAMP 2.
 BINDING 335 335 cAMP 2.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylalanine; in cAMP-dependent
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 83 83 Phosphoserine (By similarity).
 MOD_RES 101 101 Phosphoserine (By similarity).
 DISULFID 18 18 Interchain (with C-39) (By similarity).
 DISULFID 39 39 Interchain (with C-18) (By similarity).  

Keyword

 Acetylation; cAMP; cAMP-binding; Cell membrane; Complete proteome; Disulfide bond; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030552; F:cAMP binding; IDA:RGD.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IDA:RGD.
 GO:0034236; F:protein kinase A catalytic subunit binding; IC:RGD.
 GO:0060038; P:cardiac muscle cell proliferation; IEA:Compara.
 GO:0007143; P:female meiosis; IEP:RGD.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0045835; P:negative regulation of meiosis; IEP:RGD.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 

Pfam

 PF00027; cNMP_binding
 PF02197; RIIa 

SMART

 SM00100; cNMP
 SM00394; RIIa 

PROSITE

 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 

PRINTS

 PR00103; CAMPKINASE.