UniProt Accession

 CANB1_HUMAN; P63098; B2RC10; B5MDU4; P06705; P15117; Q08044; Q53SL0 

Genbank Protein ID

 M30773; CR456938; AK314893; AC017083; CH471053; BC027913 

Genbank Nucleotide ID

 AAB08721.1; CAG33219.1; BAG37407.1; AAY14715.1; EAW99878.1; AAH27913.1 

Protein Name

 Calcineurin subunit B type 1 

Protein Synonyms/Alias

 Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1 

Gene Name

 PPP3R1 

Gene Synonyms/Alias

 CNA2; CNB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	RLGKRFKKLDLDNSG	ubiquitination	[1]
103	FRIYDMDKDGYISNG	ubiquitination	[1]
125	MMVGNNLKDTQLQQI	ubiquitination	[1, 2]
165	GGLDIHKKMVVDV**	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. 

Sequence Annotation

 DOMAIN 18 51 EF-hand 1.
 DOMAIN 50 85 EF-hand 2.
 DOMAIN 87 122 EF-hand 3.
 DOMAIN 128 163 EF-hand 4.
 MOD_RES 106 106 Phosphotyrosine (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 3D-structure; Calcium; Complete proteome; Direct protein sequencing; Lipoprotein; Metal-binding; Myristate; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005955; C:calcineurin complex; NAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity; NAS:UniProtKB.
 GO:0005516; F:calmodulin binding; NAS:UniProtKB.
 GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome.
 GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5
 PF00036; efhand 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS