UniProt Accession

 DNPEP_MOUSE; Q9Z2W0; Q56A00 

Genbank Protein ID

 AF005051; AK166276; CH466548; CH466548; CH466548; CH466548; BC092232 

Genbank Nucleotide ID

 AAD01212.1; BAE38675.1; EDL00396.1; EDL00398.1; EDL00400.1; EDL00401.1; AAH92232.1 

Protein Name

 Aspartyl aminopeptidase 

Protein Synonyms/Alias

  

Gene Name

 Dnpep 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	ATARELLKFVNRSPS	acetylation	[1]
21	ATARELLKFVNRSPS	ubiquitination	[2]
61	WDIVPENKYFLTRNS	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity). 

Sequence Annotation

 METAL 92 92 Zinc 1 (By similarity).
 METAL 262 262 Zinc 1 (By similarity).
 METAL 262 262 Zinc 2 (By similarity).
 METAL 300 300 Zinc 2 (By similarity).
 METAL 344 344 Zinc 1 (By similarity).
 METAL 438 438 Zinc 2 (By similarity).
 BINDING 168 168 Substrate (By similarity).
 BINDING 299 299 Substrate (By similarity).
 BINDING 344 344 Substrate (By similarity).
 BINDING 347 347 Substrate (By similarity).
 BINDING 372 372 Substrate (By similarity).
 BINDING 379 379 Substrate (By similarity).  

Keyword

 Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 473 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001948; Peptidase_M18.
 IPR023358; Peptidase_M18_dom2. 

Pfam

 PF02127; Peptidase_M18 

SMART

  

PROSITE

  

PRINTS

 PR00932; AMINO1PTASE.