CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009074
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exosome component 10 
Protein Synonyms/Alias
 Autoantigen PM/Scl 2 homolog; Polymyositis/scleroderma autoantigen 2 homolog 
Gene Name
 Exosc10 
Gene Synonyms/Alias
 Pmscl2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
710AHISQAAKFDPSSKIacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA (By similarity). 
Sequence Annotation
 DOMAIN 503 583 HRDC.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Exonuclease; Exosome; Hydrolase; Nonsense-mediated mRNA decay; Nuclease; Nucleus; Reference proteome; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 887 AA 
Protein Sequence
MAPPSPREHQ SAPATSATKP DAEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY 60
DFYRSFPAFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDTNDVI 120
LERVGMLLDE ASGVNKHQQP VLPAGLQVPK TIVSSWNRKA GEYGKKAKSE TFRLLHAKNI 180
VRPQLRFREK IDNSNTPFLP KIFVKPNARK PLPLALSKER RERPQDRPED LDVPPALADF 240
IHQQRTQQVE QDMFAHPYQY ELDHFTPPQS VLQRPKPQLY RAVGETPCHL VSSLDELVEL 300
NEKLLGCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFIV DTLELRSDMY ILNESLTDPA 360
IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLAR HSLDHLLRLY CGVESNKQYQ 420
LADWRIRPLP EEMLSYARDD THYLLYIYDR MRLELWERGN HQPVQLQVVW QRSRDICLKK 480
FVKPIFTDES YLELYRKQKK HLNSQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI 540
AEELPKEPQG IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSENAAGV RKSGPLPSAE 600
RLENDLFGPH DCSHAPPDNY QNTSTDGTLP LQKQPSLFTE GKEETSVDAG CLLATAVITL 660
FSEPNTEEGG KTPLTVAQKK AQNIMQSFEN PFRMFLPSLE HKAHISQAAK FDPSSKIYEI 720
SNRWKLASQV QVQKEPKEAT KKKVAEQTAA REEAKEEAAA GVLEQAIPVR QQAALENATK 780
KRERATSDLR TIEQKQEKKR LKSSKKAKDP DPPGKDFSPY DYSQSDFRAF AGDSKSKPSS 840
QFDPNKLAPS GKKGVGAKKC KQSVGNKSMS FAVGKSDRGF RHNWPKR 887 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.
 GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0035327; C:transcriptionally active chromatin; IEA:Compara.
 GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
 GO:0004532; F:exoribonuclease activity; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0071034; P:CUT catabolic process; IEA:Compara.
 GO:0009048; P:dosage compensation by inactivation of X chromosome; IMP:MGI.
 GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB.
 GO:0000460; P:maturation of 5.8S rRNA; IEA:Compara.
 GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IEA:Compara.
 GO:0071048; P:nuclear retention of unspliced pre-mRNA at the site of transcription; IEA:Compara.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR002562; 3'-5'_exonuclease_dom.
 IPR012588; Exosome-assoc_fac_Rrp6_N.
 IPR010997; HRDC-like.
 IPR002121; HRDC_dom.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF01612; DNA_pol_A_exo1
 PF00570; HRDC
 PF08066; PMC2NT 
SMART
 SM00474; 35EXOc
 SM00341; HRDC 
PROSITE
 PS50967; HRDC 
PRINTS