CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023348
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polycomb protein Asx 
Protein Synonyms/Alias
 Additional sex combs 
Gene Name
 Asx 
Gene Synonyms/Alias
 CG8787 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
88HLPRIIVKPIPPEKKacetylation[1]
536KEMIVAMKQVDSKEDacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development. PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development. 
Sequence Annotation
 ZN_FING 1632 1669 PHD-type; atypical.
 MOTIF 224 228 LXXLL motif 1.
 MOTIF 244 248 LXXLL motif 2.  
Keyword
 Chromatin regulator; Chromosome; Complete proteome; Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1669 AA 
Protein Sequence
MKTITPDTTT TTSSQHQQLL IPQADQHHQP MLQQQSLLAA PPPTMIMEHV NLVDDDEKDP 60
LALEQLEVSP STKHTHSLRR HLPRIIVKPI PPEKKPMAPS EEAAVSTAPA PPTRLICSRR 120
IQQQQQVKAA AAAAAAAAAA AAAAAAAAQA QATSSYPSAI SPGSKAGTSQ ASTMREVLAS 180
IPGFSVKPRR RSNKKLTTAA QIEQTKDGKI DLETPDSILA STNLRALLNK QTFSLLPPLY 240
QYNLIQLLPS VDREASELEQ PSSSASGGSP SEAIRLSASC LNNEFFARAC LEWRERLSEG 300
EFTPENQLKL KTEAEREKNK LDPWKLKHFE PFWGEKNSRG KDKDKLESDC KNQKLSASIK 360
SEPKPPATSQ QKPLQQATCD NETELKFDLS TKCETTSAKT TVAVAVADKS STFPPTGSQN 420
NVLNEQQRRV LKRPSSSPSQ RKQAPTTIAT INLDDDLDEL PSTSKDSKQP KMDEIVPNAS 480
GNVVAAPMVD VVDHSAVEMK IKDEQQHQRQ HQPLINSTCD KIEPSECSKE MIVAMKQVDS 540
KEDVDSIASA AAMPAIAAVT PHTPKPEALA PNPDVANQFV SYLQNVELAA ETKAPLDNSN 600
EADITTGTNS HDFVFSDTID HAYFQEHQST INHNFFTSSS SSNTATTAAN KLEEHSDKPE 660
DSPLPIASSI SGSTPASSIT STSCTSSSSS SASMSSSCSS SNSGSTTTAP TTSSSAGAPT 720
APLTLAAAAE TTLANVQAML STVAKLQQQQ QELPVELNSN EMYQHVQHDW NFGDIKLSSS 780
QSSGDQQRNL SHEAIDLMDV VQDADVIDDI MHNDVCHDVL GDEDEGDQEE DEDDEVVECM 840
TEEQQLIDED SEAVREIVDK LQQHQQQQNQ QQHHQQLHIQ DVVQLAQHSF MPQAHSEFGN 900
DIGQEMLCDA VPMSAAEMEV SSTVITNSSN SNDSSNNISL CSSTNSLTIN QMPHQASQQP 960
QQNAQSNAQQ QRQILVDSNG QIIGNFLLQQ QRQQQQQQLL QQFTLQAAAA QQQQQQQQQH 1020
QQQQQQQQQA TSSNSLGKTL PVALRNGTQQ FLSPNLIAQQ HQQQQQQQLE QHQQQATAQQ 1080
KHQQIQQFAL QQAQLHQRQL LAQAANNNLL QQQQQQQQNV ALPTTQAKFI AKPLNIISMT 1140
RPANASPTTA ATTANTASIP SAYANVVAVT GAQQQQSPPV PAPQQQTVQQ QQLANHNSNM 1200
QQLPNVLTMK TLPPSGVPTT IAQQRLQPKM PTGKGRKATS NRLPPGAVNL ERSYQICQAV 1260
IQNSPNRENL KAQLRPPAAI LNQHQPTTTT APAPINPVTL NVSTVAATPM SNITTATGSM 1320
AAAVAAAPPQ NVLKQEELLV SGAVGAGALP AGLPPNVMGV GRPGVYKVIG PRMSGFPRKK 1380
YVQRKPSPTT LIRHVFSPGP GGATATAQQL QMLQQHHQST TSPVPVQNPQ QPAPEQLIHQ 1440
NGNGQYVLVH RANVGAADNQ APRASSAPPM HQNQFVTVQN PLHSINGIPM GGRGRPASVD 1500
TTAGSGNVIA PPISATDALH HHHHEMQQQQ QHQQPQPLGN VGAAANIVRR NIAAGPNIAY 1560
IDGSNTNSSA VALMEAGNNY IVTTNASPTA APSPINQQPQ SQPTGTQHQH PLLQLHQTGE 1620
NTPPGNEATA TANNCACSLN AMVICQQCGA FCHDDCIGAA KLCVACVIR 1669 
Gene Ontology
 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0035517; C:PR-DUB complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035800; F:ubiquitin-specific protease activator activity; IDA:FlyBase.
 GO:0007469; P:antennal development; IMP:FlyBase.
 GO:0007475; P:apposition of dorsal and ventral imaginal disc-derived wing surfaces; IMP:FlyBase.
 GO:0001709; P:cell fate determination; IGI:FlyBase.
 GO:0035522; P:monoubiquitinated histone H2A deubiquitination; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0045498; P:sex comb development; TAS:UniProtKB.
 GO:0035186; P:syncytial blastoderm mitotic cell cycle; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR026905; ASX-like_PHD.
 IPR024811; ASX/ASX-like.
 IPR024814; Polycomb_ASX. 
Pfam
 PF13922; PHD_3 
SMART
  
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS