UniProt Accession

 NEUM_RAT; P07936; A0JPM4 

Genbank Protein ID

 M16228; M16736; X06338; L21192; L21190; L21191; BC127502 

Genbank Nucleotide ID

 AAA41190.1; AAA41192.1; CAA29644.1; AAA41189.1; AAA41189.1; AAA41189.1; AAI27503.1 

Protein Name

 Neuromodulin 

Protein Synonyms/Alias

 Axonal membrane protein GAP-43; Growth-associated protein 43; Protein F1 

Gene Name

 Gap43 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
19	EKNDEDQKIEQDGVK	ubiquitination	[1]
26	KIEQDGVKPEDKAHK	acetylation	[2]
26	KIEQDGVKPEDKAHK	ubiquitination	[1]
30	DGVKPEDKAHKAATK	ubiquitination	[1]
37	KAHKAATKIQASFRG	ubiquitination	[1]
56	KKLKDEKKGDAPAAE	ubiquitination	[1]
67	PAAEAEAKEKDDAPV	ubiquitination	[1]
69	AEAEAKEKDDAPVAD	ubiquitination	[1]
81	VADGVEKKEGDGSAT	ubiquitination	[1]
98	AAPATSPKAEEPSKA	ubiquitination	[1]
125	DAAPSEEKAGSAETE	ubiquitination	[1]
136	AETESAAKATTDNSP	ubiquitination	[1]
198	SSQAEEEKEAVDEAK	acetylation	[2]
205	KEAVDEAKPKESARQ	acetylation	[2]
216	SARQDEGKEDPEADQ	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). 

Sequence Annotation

 DOMAIN 31 60 IQ.
 REGION 1 4 Important for membrane binding (By
 MOD_RES 41 41 Phosphoserine; by PHK and PKC.
 MOD_RES 95 95 Phosphothreonine (By similarity).
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 103 103 Phosphoserine (By similarity).
 MOD_RES 172 172 Phosphothreonine.
 MOD_RES 191 191 Phosphoserine; by CK2 (By similarity).
 MOD_RES 192 192 Phosphoserine; by CK2 (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).
 LIPID 4 4 S-palmitoyl cysteine (By similarity).  

Keyword

 Calmodulin-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Growth regulation; Lipoprotein; Membrane; Neurogenesis; Palmitate; Phosphoprotein; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; TAS:RGD.
 GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0016198; P:axon choice point recognition; IEA:Compara.
 GO:0045165; P:cell fate commitment; IEA:Compara.
 GO:0010001; P:glial cell differentiation; IEA:Compara.
 GO:0007399; P:nervous system development; IEP:RGD.
 GO:0051489; P:regulation of filopodium assembly; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0042246; P:tissue regeneration; IEP:RGD. 

Interpro

 IPR000048; IQ_motif_EF-hand-BS.
 IPR001422; Neuromodulin.
 IPR017454; Neuromodulin_C.
 IPR018947; Neuromodulin_gap-junction_N.
 IPR018243; Neuromodulin_palmitoyl/P_site. 

Pfam

 PF00612; IQ
 PF06614; Neuromodulin
 PF10580; Neuromodulin_N 

SMART

 SM00015; IQ 

PROSITE

 PS50096; IQ
 PS00412; NEUROMODULIN_1
 PS00413; NEUROMODULIN_2 

PRINTS

 PR00215; NEUROMODULIN.