CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041537
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptotagmin II 
Protein Synonyms/Alias
 Synaptotagmin-2 
Gene Name
 Syt2 
Gene Synonyms/Alias
 rCG_46525 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
106KEKGKGMKNAMNMKDubiquitination[1]
190KVFLLPDKKKKYETKacetylation[2]
191VFLLPDKKKKYETKVubiquitination[1]
322IHLMQNGKRLKKKKTacetylation[2]
409IAQWHSLKPEEEVDAacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MRNIFKRNQE PIVAPATTTA TMPLAPAAPV DNSTESTGTG ESQEDMFAKL KDKFFNEINK 60
IPLPPWALIA MAVVAGLLLL TCCFCICKKC CCKKKKNKKE KGKGMKNAMN MKDMKGGQDD 120
DDAETGLTEG EGEGEEEKEP ENLGKLQFSL DYDFQANQLT VGVLQAAELP ALDMGGTSDP 180
YVKVFLLPDK KKKYETKVHR KTLNPAFNET FTFKVPYQEL GGKTLVMAIY DFDRFSKHDI 240
IGEVKVPMNT VDLGQPIEEW RDLQGGEKEE PEKLGDICTS LRYVPTAGKL TVCILEAKNL 300
KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT VKKKTLNPYF NESFSFEIPF EQIQKVQVVV 360
TVLDYDKLGK NEAIGKIFVG SNATGTELRH WSDMLANPRR PIAQWHSLKP EEEVDALLGK 420
NK 422 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:Compara.
 GO:0005215; F:transporter activity; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR001565; Synaptotagmin. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS
 PR00360; C2DOMAIN.
 PR00399; SYNAPTOTAGMN.