| Tag | Content |
|---|
| CPLM ID | CPLM-023036 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium-binding mitochondrial carrier protein Aralar2 |
Protein Synonyms/Alias | Citrin; Mitochondrial aspartate glutamate carrier 2; Solute carrier family 25 member 13 |
Gene Name | SLC25A13 |
Gene Synonyms/Alias | ARALAR2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 409 | VAPEKAIKLTVNDFV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. |
Sequence Annotation | DOMAIN 51 86 EF-hand 1.
DOMAIN 87 122 EF-hand 2.
DOMAIN 125 157 EF-hand 3.
DOMAIN 158 193 EF-hand 4.
REPEAT 326 418 Solcar 1.
REPEAT 426 510 Solcar 2.
REPEAT 518 606 Solcar 3.
MOD_RES 484 484 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Calcium; Complete proteome; Disease mutation; Intrahepatic cholestasis; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 675 AA |
Protein Sequence | MAAAKVALTK RADPAELRTI FLKYASIEKN GEFFMSPNDF VTRYLNIFGE SQPNPKTVEL 60
LSGVVDQTKD GLISFQEFVA FESVLCAPDA LFMVAFQLFD KAGKGEVTFE DVKQVFGQTT 120
IHQHIPFNWD SEFVQLHFGK ERKRHLTYAE FTQFLLEIQL EHAKQAFVQR DNARTGRVTA 180
IDFRDIMVTI RPHVLTPFVE ECLVAAAGGT TSHQVSFSYF NGFNSLLNNM ELIRKIYSTL 240
AGTRKDVEVT KEEFVLAAQK FGQVTPMEVD ILFQLADLYE PRGRMTLADI ERIAPLEEGT 300
LPFNLAEAQR QQKASGDSAR PVLLQVAESA YRFGLGSVAG AVGATAVYPI DLVKTRMQNQ 360
RSTGSFVGEL MYKNSFDCFK KVLRYEGFFG LYRGLLPQLL GVAPEKAIKL TVNDFVRDKF 420
MHKDGSVPLA AEILAGGCAG GSQVIFTNPL EIVKIRLQVA GEITTGPRVS ALSVVRDLGF 480
FGIYKGAKAC FLRDIPFSAI YFPCYAHVKA SFANEDGQVS PGSLLLAGAI AGMPAASLVT 540
PADVIKTRLQ VAARAGQTTY SGVIDCFRKI LREEGPKALW KGAGARVFRS SPQFGVTLLT 600
YELLQRWFYI DFGGVKPMGS EPVPKSRINL PAPNPDHVGG YKLAVATFAG IENKFGLYLP 660
LFKPSVSTSK AIGGGP 676 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB. GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. GO:0005509; F:calcium ion binding; IDA:UniProtKB. GO:0015183; F:L-aspartate transmembrane transporter activity; IDA:UniProtKB. GO:0005313; F:L-glutamate transmembrane transporter activity; IDA:UniProtKB. GO:0006754; P:ATP biosynthetic process; IDA:UniProtKB. GO:0006094; P:gluconeogenesis; TAS:Reactome. GO:0043490; P:malate-aspartate shuttle; IDA:UniProtKB. GO:0051592; P:response to calcium ion; IDA:UniProtKB. |
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