CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032864
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-CoA synthetase 
Protein Synonyms/Alias
  
Gene Name
 PFF1350c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
658TALRALMKYGDEWIQacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 997 AA 
Protein Sequence
MNNLKSYGSL SKVDSVQING MDIDTNIFLN MNSYPTKEIY DDENNKNDGN HNIKNFQAYK 60
AMYEESINNP EAFWGNLAKN NLIWYKLFTK VFLGNFKKGN INWFVNGKIN ACENCVDRWV 120
EKDPNKIALI WEQDCPDQYK KITYQKLLEK TCKVANLLKL IGVKKQDTVT IYLPMIPELI 180
YSMLACVRIG AIHNVVFAGY SAASLSDRII DSRSTVLITS DFGLRGGKLT KLKQIADVAM 240
DMCGMIQTCI VFKNKTKMKD KNIQIKTPME NPIYNFTSFD SNSAQNFTIN NSNDFIQIKS 300
THSHQSDHQN DFSLQQEDNN YTKNSNMSYT TSMYYHDNNL NHINTNKNND HYNNNLNNKN 360
YLNNNINDQS PMYVHTMNHN DNNDDNNNNN NNNNVDDDNN SNIQNDEQSY FNQQNNTYNK 420
NDHSDDNNKN KGKTTLHKKI TKNNPINHKI SYSEKSYSKE LINTDMVNND NQFGDLKTKK 480
KFININNIIT CNQNGYSTNK QYFPEPDKNS TSNFDETLCV LKKGRDIDGT ALLKNMRSYC 540
PIEYVDSEDF LFLLYTSGST GKPKGVAHTT AGYLLYAYTT CKYIFDVKEN DIFGCVADIG 600
WVTGHTYVLY GPLLNGITTV IFSSIPTYPD CGRYWSLIQT HKVTQFYTAP TALRALMKYG 660
DEWIQKYDLS SCRILGSVGE PINPETWRWY YNVVGKKKCT IVDTYWQTET GGIVIAPIPH 720
LFSMKPGCAS LPFLGVQLEI LDSKTLQPLS GNNVCGLLCI KSPWPGMLRT VYGNHQRLIK 780
TYFTMCPNYY FTGDGAFRDE DGYYWISGRI DDTLNVAGHR LGAAEIEHAL VQHFYIAEAA 840
VVSFHHNVKG EGILCFVVKK KGDIKNYSKG ITDIVNSNNN NNRNELHNNS PFLICSNNIT 900
DIEEFKKNFT DEKLIEQLKL YVRQVIGPIA TPDLICVVPD LPKTRSGKIV RRILRCIANG 960
ITDFGDISTV SNYEVIETIN NTLIECKKKL KHIEIKK 997 
Gene Ontology
 GO:0003987; F:acetate-CoA ligase activity; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR024597; Acyl-CoA_synth_DUF3448.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR025110; DUF4009. 
Pfam
 PF00501; AMP-binding
 PF11930; DUF3448
 PF13193; DUF4009 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS