CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029251
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GA binding protein transcription factor alpha subunit 60kDa 
Protein Synonyms/Alias
 GA binding protein transcription factor, alpha subunit 60kDa; GA binding protein transcription factor, alpha subunit 60kDa, isoform CRA_a; Nuclear respiratory factor 2 alpha subunit 
Gene Name
 GABPA 
Gene Synonyms/Alias
 hCG_401151 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
359QPELVAQKWGQRKNKubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 DNA-binding; Nucleus. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN LKKLLEPRLQ 60
CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS YQGIEPKLNI LEIVKPADTV 120
EVVIDPDAHH AESEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL 180
GIPYDPIQWS TDQVLHWVVW VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL 240
WSHLELLRKY VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP 300
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL NQPELVAQKW 360
GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV CDLKTLIGYS AAELNRLVTE 420
CEQKKLAKMQ LHGIAQPVTA VALATASLQT EKDN 454 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR000418; Ets_dom.
 IPR024668; GABP_asu_N.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR016312; TF_GA-bd_asu.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets
 PF11620; GABP-alpha
 PF02198; SAM_PNT 
SMART
 SM00413; ETS
 SM00251; SAM_PNT 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 
PRINTS
 PR00454; ETSDOMAIN.