UniProt Accession

 RASK_HUMAN; P01116; A8K8Z5; B0LPF9; P01118; Q96D10 

Genbank Protein ID

 L00049; L00045; L00046; L00047; L00048; L00045; L00046; L00047; M54968; AF493917; BT007153; AK292510; CH471094; CH471094; EU332849; BC013572; K01519; K01520; M25876; M34904; M30539; X01669; X02825; K03210; K03209 

Genbank Nucleotide ID

 AAB59444.1; AAB59444.1; AAB59444.1; AAB59444.1; AAB59445.1; AAB59445.1; AAB59445.1; AAB59445.1; AAB41942.1; AAM12631.1; AAP35817.1; BAF85199.1; EAW96511.1; EAW96512.1; ABY87538.1; AAH13572.1; AAA35683.1; AAA36149.1; AAA36557.1; CAA25828.1; CAA26593.1; AAA36554.1; AAA36554.1 

Protein Name

 GTPase KRas 

Protein Synonyms/Alias

 K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase KRas, N-terminally processed 

Gene Name

 KRAS 

Gene Synonyms/Alias

 KRAS2; RASK2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
104	REQIKRVKDSEDVPM	acetylation	[1]

Reference

 [1] Regulation of RAS oncogenicity by acetylation.
 Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.
 Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8. [PMID: 22711838] 

Functional Description

 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 10 17 GTP.
 NP_BIND 57 61 GTP.
 NP_BIND 116 119 GTP.
 REGION 166 185 Hypervariable region.
 MOTIF 32 40 Effector region.
 MOD_RES 1 1 N-acetylmethionine; in GTPase KRas;
 MOD_RES 2 2 N-acetylthreonine; in GTPase KRas, N-
 MOD_RES 104 104 N6-acetyllysine.
 MOD_RES 186 186 Cysteine methyl ester.
 LIPID 180 180 S-palmitoyl cysteine.
 LIPID 186 186 S-farnesyl cysteine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cardiomyopathy; Cell membrane; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Polymorphism; Prenylation; Proto-oncogene; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0019002; F:GMP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0000165; P:MAPK cascade; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0051385; P:response to mineralocorticoid stimulus; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.