CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006163
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome b-c1 complex subunit 2, mitochondrial 
Protein Synonyms/Alias
 Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2 
Gene Name
 Uqcrc2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
65SRIGLFIKAGSRYENacetylation[1]
91LASTLTTKGASSFKIacetylation[1]
97TKGASSFKITRGIEAacetylation[1]
158AALRSQLKIDKAVAFacetylation[1]
161RSQLKIDKAVAFQNPacetylation[1]
198CPDYRMGKITSEELHacetylation[1]
251GLAGAKAKYRGGEIRacetylation[1]
429DVVKAAKKFVSGKKSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. 
Sequence Annotation
 MOD_RES 158 158 N6-acetyllysine (By similarity).
 MOD_RES 249 249 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transit peptide; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MKLLSRAGSF SRFYSLKVAP KLKTSAPGGV PLQPQELEFT KLPNGLVIAS LENYAPLSRI 60
GLFIKAGSRY ENYNYLGTSH LLRLASTLTT KGASSFKITR GIEAVGGKLS VTATRENMAY 120
TVEGIRDDIE ILMEFLLNVT TAPEFRRWEV AALRSQLKID KAVAFQNPQT RIIENLHDVA 180
YKNALANPLY CPDYRMGKIT SEELHYFVQN HFTSARMALV GLGVSHSILK EVAEQFLNIR 240
GGLGLAGAKA KYRGGEIREQ NGDNLVHAAI VAESAAIGNA EANAFSVLQH LLGAGPHIKR 300
GNNTTSLLSQ SVAKGSQQPF DVSAFNASYS DSGLFGIYTV SQAAAAGDVI NAAYNQVKAV 360
AQGNLSSADV QAAKNKLKAG YLMSVETSEG FLSEIGSQAL ATGSYMPPPT VLQQIDAVAD 420
ADVVKAAKKF VSGKKSMTAS GNLGHTPFLD EL 452 
Gene Ontology
 GO:0005750; C:mitochondrial respiratory chain complex III; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR001431; Pept_M16_Zn_BS.
 IPR007863; Peptidase_M16_C. 
Pfam
 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 
SMART
  
PROSITE
 PS00143; INSULINASE 
PRINTS