CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015458
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Immunoglobulin superfamily member 10 
Protein Synonyms/Alias
 IgSF10; Calvaria mechanical force protein 608; CMF608 
Gene Name
 IGSF10 
Gene Synonyms/Alias
 CMF608 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
471EMRPVKHKWTMISRDacetylation[1]
516WLLADGSKVRAPYVSacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). 
Sequence Annotation
 DOMAIN 29 56 LRRNT.
 REPEAT 58 79 LRR 1.
 REPEAT 82 103 LRR 2.
 REPEAT 106 127 LRR 3.
 REPEAT 130 151 LRR 4.
 REPEAT 154 175 LRR 5.
 REPEAT 186 207 LRR 6.
 DOMAIN 219 281 LRRCT.
 DOMAIN 461 567 Ig-like C2-type 1.
 DOMAIN 571 661 Ig-like C2-type 2.
 DOMAIN 1648 1739 Ig-like C2-type 3.
 DOMAIN 1745 1836 Ig-like C2-type 4.
 DOMAIN 1841 1933 Ig-like C2-type 5.
 DOMAIN 1941 2034 Ig-like C2-type 6.
 DOMAIN 2037 2135 Ig-like C2-type 7.
 DOMAIN 2141 2229 Ig-like C2-type 8.
 DOMAIN 2234 2331 Ig-like C2-type 9.
 DOMAIN 2337 2427 Ig-like C2-type 10.
 DOMAIN 2432 2518 Ig-like C2-type 11.
 DOMAIN 2528 2623 Ig-like C2-type 12.
 MOD_RES 2603 2603 Phosphotyrosine (By similarity).
 CARBOHYD 319 319 N-linked (GlcNAc...) (Potential).
 CARBOHYD 439 439 N-linked (GlcNAc...) (Potential).
 CARBOHYD 627 627 N-linked (GlcNAc...) (Potential).
 CARBOHYD 774 774 N-linked (GlcNAc...) (Potential).
 CARBOHYD 999 999 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1899 1899 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1962 1962 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2101 2101 N-linked (GlcNAc...) (Potential).
 DISULFID 497 551 By similarity.
 DISULFID 595 645 By similarity.
 DISULFID 1670 1723 By similarity.
 DISULFID 1767 1820 By similarity.
 DISULFID 1864 1917 By similarity.
 DISULFID 1963 2016 By similarity.
 DISULFID 2060 2119 By similarity.
 DISULFID 2163 2213 By similarity.
 DISULFID 2261 2313 By similarity.
 DISULFID 2359 2411 By similarity.
 DISULFID 2454 2506 By similarity.
 DISULFID 2550 2605 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Osteogenesis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2623 AA 
Protein Sequence
MKVKGRGITC LLVSFAVICL VATPGGKACP RRCACYMPTE VHCTFRYLTS IPDSIPPNVE 60
RINLGYNSLV RLMETDFSGL TKLELLMLHS NGIHTIPDKT FSDLQALQVL KMSYNKVRKL 120
QKDTFYGLRS LTRLHMDHNN IEFINPEVFY GLNFLRLVHL EGNQLTKLHP DTFVSLSYLQ 180
IFKISFIKFL YLSDNFLTSL PQEMVSYMPD LDSLYLHGNP WTCDCHLKWL SDWIQEKPDV 240
IKCKKDRSPS SAQQCPLCMN PRTSKGKPLA MVSAAAFQCA KPTIDSSLKS KSLTILEDSS 300
SAFISPQGFM APFGSLTLNM TDQSGNEANM VCSIQKPSRT SPIAFTEEND YIVLNTSFST 360
FLVCNIDYGH IQPVWQILAL YSDSPLILER SHLLSETPQL YYKYKQVAPK PEDIFTNIEA 420
DLRADPSWLM QDQISLQLNR TATTFSTLQI QYSSDAQITL PRAEMRPVKH KWTMISRDNN 480
TKLEHTVLVG GTVGLNCPGQ GDPTPHVDWL LADGSKVRAP YVSEDGRILI DKSGKLELQM 540
ADSFDTGVYH CISSNYDDAD ILTYRITVVE PLVEAYQENG IHHTVFIGET LDLPCHSTGI 600
PDASISWVIP GNNVLYQSSR DKKVLNNGTL RILQVTPKDQ GYYRCVAANP SGVDFLIFQV 660
SVKMKGQRPL EHDGETEGSG LDESNPIAHL KEPPGAQLRT SALMEAEVGK HTSSTSKRHN 720
YRELTLQRRG DSTHRRFREN RRHFPPSARR IDPQHWAALL EKAKKNAMPD KRENTTVSPP 780
PVVTQLPNIP GEEDDSSGML ALHEEFMVPA TKALNLPART VTADSRTISD SPMTNINYGT 840
EFSPVVNSQI LPPEEPTDFK LSTAIKTTAM SKNINPTMSS QIQGTTNQHS STVFPLLLGA 900
TEFQDSDQMG RGREHFQSRP PITVRTMIKD VNVKMLSSTT NKLLLESVNT TNSHQTSVRE 960
VSEPRHNHFY SHTTQILSTS TFPSDPHTAA HSQFPIPRNS TVNIPLFRRF GRQRKIGGRG 1020
RIISPYRTPV LRRHRYSIFR STTRGSSEKS TTAFSATVLN VTCLSCLPRE RLTTATAALS 1080
FPSAAPITFP KADIARVPSE ESTTLVQNPL LLLENKPSVE KTTPTIKYFR TEISQVTPTG 1140
AVMTYAPTSI PMEKTHKVNA SYPRVSSTNE AKRDSVITSS LSGAITKPPM TIIAITRFSR 1200
RKIPWQQNFV NNHNPKGRLR NQHKVSLQKS TAVMLPKTSP ALPRDKVSPF HFTTLSTSVM 1260
QIPSNTLTTA HHTTTKTHNP GSLPTKKELP FPPLNPMLPS IISKDSSTKS IISTQTAIPA 1320
TTPTFPASVI TYETQTERSR AQTIQREQEP QKKNRTDPNI SPDQSSGFTT PTAMTPPVLT 1380
TAETSVKPSV SAFTHSPPEN TTGISSTISF HSRTLNLTDV IEELAQASTQ TLKSTIASET 1440
TLSSKSHQST TTRKAIIRHS TIPPFLSSSA TLMPVPISPP FTQRAVTDNV ATPISGLMTN 1500
TVVKLHESSR HNAKPQQLVA EVATSPKVHP NAKFTIGTTH FIYSNLLHST PMPALTTVKS 1560
QNSKLTPSPW AENQFWHKPY SEIAEKGKKP EVSMLATTGL SEATTLVSDW DGQKNTKKSD 1620
FDKKPVQEAT TSKLLPFDSL SRYIFEKPRI VGGKAASFTI PANSDAFLPC EAVGNPLPTI 1680
HWTRVPSGLD LSKRKQNSRV QVLPNGTLSI QRVEIQDRGQ YLCSASNLFG TDHLHVTLSV 1740
VSYPPRILER RTKEITVHSG STVELKCRAE GRPSPTVTWI LANQTVVSES SQGSRQAVVT 1800
VDGTLVLHNL SIYDRGFYKC VASNPGGQDS LLVKIQVIAA PPVILEQRRQ VIVGTWGESL 1860
KLPCTAKGTP QPSVYWVLSD GTEVKPLQFT NSKLFLFSNG TLYIRNLASS DRGTYECIAT 1920
SSTGSERRVV MLTMEERVTS PRIEAASQKR TEVNFGDKLL LNCSATGEPK PQIMWRLPSK 1980
AVVDQQHRVG SWIHVYPNGS LFIGSVTEKD SGVYLCVARN KMGDDLILMH VSLRLKPAKI 2040
DHKQYFRKQV LHGKDFQVDC KASGSPVPEI SWSLPDGTMI NNAMQADDSG HRTRRYTLFN 2100
NGTLYFNKVG VAEEGDYTCY AQNTLGKDEM KVHLTVITAA PRIRQSNKTN KRIKAGDTAV 2160
LDCEVTGDPK PKIFWLLPSN DMISFSIDRY TFHANGSLTI NKVKLLDSGE YVCVARNPSG 2220
DDTKMYKLDV VSKPPLINGL YTNRTVIKAT AVRHSKKHFD CRAEGTPSPE VMWIMPDNIF 2280
LTAPYYGSRI TVHKNGTLEI RNVRLSDSAD FICVARNEGG ESVLVVQLEV LEMLRRPTFR 2340
NPFNEKIVAQ LGKSTALNCS VDGNPPPEII WILPNGTRFS NGPQSYQYLI ASNGSFIISK 2400
TTREDAGKYR CAARNKVGYI EKLVILEIGQ KPVILTYAPG TVKGISGESL SLHCVSDGIP 2460
KPNIKWTMPS GYVVDRPQIN GKYILHDNGT LVIKEATAYD RGNYICKAQN SVGHTLITVP 2520
VMIVAYPPRI TNRPPRSIVT RTGAAFQLHC VALGVPKPEI TWEMPDHSLL STASKERTHG 2580
SEQLHLQGTL VIQNPQTSDS GIYKCTAKNP LGSDYAATYI QVI 2623 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0001503; P:ossification; IEA:UniProtKB-KW. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
 PF07679; I-set 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS50835; IG_LIKE 
PRINTS