UniProt Accession

 B1AXW3_MOUSE; B1AXW3 

Genbank Protein ID

 AL831786 

Genbank Nucleotide ID

  

Protein Name

 Alcohol dehydrogenase [NADP(+)] 

Protein Synonyms/Alias

  

Gene Name

 Akr1a1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	VLLHTGQKMPLIGLG	ubiquitination	[1]
23	LIGLGTWKSEPGQVK	acetylation	[2, 3, 4]
23	LIGLGTWKSEPGQVK	succinylation	[4]
23	LIGLGTWKSEPGQVK	ubiquitination	[1]
30	KSEPGQVKAAIKHAL	ubiquitination	[1]
34	GQVKAAIKHALSAGY	acetylation	[3]
34	GQVKAAIKHALSAGY	ubiquitination	[1]
68	KESVGSGKAVPREEL	acetylation	[4]
68	KESVGSGKAVPREEL	succinylation	[4]
68	KESVGSGKAVPREEL	ubiquitination	[1]
85	TSKLWNTKHHPEDVE	acetylation	[3]
85	TSKLWNTKHHPEDVE	ubiquitination	[1]
127	RGDNPFPKNADGTVR	acetylation	[2, 3, 4, 5, 6, 7, 8]
127	RGDNPFPKNADGTVR	succinylation	[4]
127	RGDNPFPKNADGTVR	ubiquitination	[1]
141	RYDSTHYKETWKALE	acetylation	[2, 3]
141	RYDSTHYKETWKALE	ubiquitination	[1]
145	THYKETWKALEVLVA	acetylation	[4]
145	THYKETWKALEVLVA	succinylation	[4]
145	THYKETWKALEVLVA	ubiquitination	[1]
153	ALEVLVAKGLVKALG	acetylation	[3]
153	ALEVLVAKGLVKALG	ubiquitination	[1]
157	LVAKGLVKALGLSNF	acetylation	[3]
157	LVAKGLVKALGLSNF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [8] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:MGI.
 GO:0047939; F:L-glucuronate reductase activity; IDA:MGI.
 GO:0046185; P:aldehyde catabolic process; IDA:MGI.
 GO:0042840; P:D-glucuronate catabolic process; IDA:MGI.
 GO:0019853; P:L-ascorbic acid biosynthetic process; IDA:MGI. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2 

PRINTS

 PR00069; ALDKETRDTASE.