| Tag | Content |
|---|
| CPLM ID | CPLM-000710 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein CBFA2T2 |
Protein Synonyms/Alias | ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85 |
Gene Name | CBFA2T2 |
Gene Synonyms/Alias | EHT; MTGR1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 408 | NENTELRKTGTELVS | ubiquitination | [1] | | 496 | EQTIADVKRQAAEDA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. |
Sequence Annotation | DOMAIN 113 208 TAFH.
ZN_FING 517 553 MYND-type.
MOD_RES 409 409 Phosphoserine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 604 AA |
Protein Sequence | MGFHHVGQAR LELLTSGDLP ALASQRAGIT VGPEKRVPAM PGSPVEVKIQ SRSSPPTMPP 60
LPPINPGGPR PVSFTPTALS NGINHSPPTL NGAPSPPQRF SNGPASSTSS ALTNQQLPAT 120
CGARQLSKLK RFLTTLQQFG NDISPEIGEK VRTLVLALVN STVTIEEFHC KLQEATNFPL 180
RPFVIPFLKA NLPLLQRELL HCARAAKQTP SQYLAQHEHL LLNTSIASPA DSSELLMEVH 240
GNGKRPSPER REENSFDRDT IAPEPPAKRV CTISPAPRHS PALTVPLMNP GGQFHPTPPP 300
LQHYTLEDIA TSHLYREPNK MLEHREVRDR HHSLGLNGGY QDELVDHRLT EREWADEWKH 360
LDHALNCIME MVEKTRRSMA VLRRCQESDR EELNYWKRRY NENTELRKTG TELVSRQHSP 420
GSADSLSNDS QREFNSRPGT GYVPVEFWKK TEEAVNKVKI QAMSEVQKAV AEAEQKAFEV 480
IATERARMEQ TIADVKRQAA EDAFLVINEQ EESTENCWNC GRKASETCSG CNIARYCGSF 540
CQHKDWERHH RLCGQNLHGQ SPHGQGRPLL PVGRGSSARS ADCSVPSPAL DKTSATTSRS 600
STPASVTAID TNGL 614 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0003714; F:transcription corepressor activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030855; P:epithelial cell differentiation; IEA:Compara. GO:0010977; P:negative regulation of neuron projection development; ISS:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |