| Tag | Content |
|---|
| CPLM ID | CPLM-020188 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MAP kinase-interacting serine/threonine-protein kinase 1 |
Protein Synonyms/Alias | MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1 |
Gene Name | MKNK1 |
Gene Synonyms/Alias | MNK1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 164 | ALDFLHTKGIAHRDL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap. |
Sequence Annotation | DOMAIN 49 374 Protein kinase.
NP_BIND 55 63 ATP (By similarity).
ACT_SITE 211 211 Proton acceptor (By similarity).
BINDING 78 78 ATP.
MOD_RES 39 39 Phosphoserine; by PAK2 (By similarity).
MOD_RES 250 250 Phosphothreonine.
MOD_RES 255 255 Phosphothreonine.
MOD_RES 385 385 Phosphothreonine.
MOD_RES 460 460 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 465 AA |
Protein Sequence | MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 60
AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 120
YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKGIAHRD LKPENILCES 180
PEKVSPVKIC DFDLGSGMKL NNSCTPITTP ELTTPCGSAE YMAPEVVEVF TDQATFYDKR 240
CDLWSLGVVL YIMLSGYPPF VGHCGADCGW DRGEVCRVCQ NKLFESIQEG KYEFPDKDWA 300
HISSEAKDLI SKLLVRDAKQ RLSAAQVLQH PWVQGQAPEK GLPTPQVLQR NSSTMDLTLF 360
AAEAIALNRQ LSQHEENELA EEPEALADGL CSMKLSPPCK SRLARRRALA QAGRGEDRSP 420
PTAL 424 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IDA:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome. GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB. GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. |
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