UniProt Accession

 PHB_RAT; P67779; P24142; Q4V8M6 

Genbank Protein ID

 M61219; BC072518; BC097304 

Genbank Nucleotide ID

 AAA63500.1; AAH72518.1; AAH97304.1 

Protein Name

 Prohibitin 

Protein Synonyms/Alias

  

Gene Name

 Phb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
83	VPVITGSKDLQNVNI	acetylation	[1]
128	SITTEILKSVVARFD	acetylation	[1]
186	FTEAVEAKQVAQQEA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. 

Sequence Annotation

 MOD_RES 202 202 N6-acetyllysine (By similarity).
 MOD_RES 249 249 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; DNA synthesis; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0031315; C:extrinsic to mitochondrial outer membrane; IDA:RGD.
 GO:0030061; C:mitochondrial crista; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0001552; P:ovarian follicle atresia; IEP:RGD.
 GO:0001541; P:ovarian follicle development; IEP:RGD.
 GO:0034097; P:response to cytokine stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD. 

Interpro

 IPR001107; Band_7.
 IPR000163; Prohibitin. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

  

PRINTS

 PR00679; PROHIBITIN.